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Opinion|Videos|May 4, 2026

Emerging Combination Strategies in Advanced Renal Cell Carcinoma

Author(s)Moshe Ornstein, MD, MA, Adam Singer, MD, Terence W. Friedlander, MD

In this forward-looking segment on advanced renal cell carcinoma, Dr. Ornstein asks the panel to consider how treatment decisions may evolve if newer combination therapies become available in the second-line setting. He introduces the potential role of lenvatinib combined with belzutifan and asks how this regimen might fit into clinical practice.

Episodes in this series

Experts featured in this series.

EP. 1 First-Line Treatment Selection in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 2 Frontline Regimen Selection in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 3 Impact of Sequencing on First-Line Decisions in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 4 Real-World Treatment Attrition in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 5 Managing Tolerability and Dose Optimization in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 6 Second-Line Treatment Decision-Making in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 7 Second-Line Utilization and Evolving Options in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 8 Case-Based Second-Line Strategy After IO in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 9 Second-Line Strategy After IO and TKI in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 10 Case-Based Sequencing After IO in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 11 Balancing Efficacy and Tolerability With TKIs in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 12 Emerging Combination Strategies in Advanced Renal Cell Carcinoma

In this forward-looking segment on advanced renal cell carcinoma, Dr. Ornstein asks the panel to consider how treatment decisions may evolve if newer combination therapies become available in the second-line setting. He introduces the potential role of lenvatinib combined with belzutifan and asks how this regimen might fit into clinical practice.

Dr. Singer discusses emerging data, noting that combination approaches have demonstrated improvements in progression-free survival and duration of response compared with single-agent therapy, while overall survival data continue to mature. He highlights the potential advantage of combining a VEGF receptor targeted therapy with a HIF-2α inhibitor to enhance efficacy without substantially increasing toxicity. Dr. Friedlander adds that the strength and maturity of clinical trial data will be important in guiding adoption, emphasizing that doublet therapy may be preferred for fit patients to maximize response. The discussion underscores that evolving evidence will continue to shape sequencing strategies in advanced renal cell carcinoma.

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