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Opinion|Videos|March 31, 2026

First-Line Treatment Selection in Advanced Renal Cell Carcinoma

Author(s)Moshe Ornstein, MD, MA, Adam Singer, MD, Terence W. Friedlander, MD

In this opening segment on advanced renal cell carcinoma, Dr. Ornstein introduces the evolving frontline treatment landscape, highlighting the expanded role of immune checkpoint inhibitor–based combinations and VEGF receptor targeted therapies.

Episodes in this series

Experts featured in this series.

EP. 1 First-Line Treatment Selection in Advanced Renal Cell Carcinoma

Experts featured in this series.

EP. 2 Frontline Regimen Selection in Advanced Renal Cell Carcinoma

In this opening segment on advanced renal cell carcinoma, Dr. Ornstein introduces the evolving frontline treatment landscape, highlighting the expanded role of immune checkpoint inhibitor–based combinations and VEGF receptor targeted therapies. He underscores the importance of selecting the most appropriate initial regimen, given the potential for durable benefit in the first-line setting.

Dr. Singer outlines his clinical approach to first-line treatment selection, emphasizing the role of IMDC risk stratification, disease burden, and patient-specific factors such as comorbidities and performance status. He also discusses how disease kinetics and the need for rapid response can influence regimen choice. The discussion reflects a practical, individualized approach to decision-making, balancing efficacy and tolerability while considering how upfront treatment choices may impact overall outcomes. This segment establishes the foundation for clinical management in advanced renal cell carcinoma.

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