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|Videos|April 18, 2022

Evolution of Combination Therapy As The Standard of Care

Author(s)David Aggen, MD, PhD, Robert S. Alter, MD, Arnab Basu, MD, MPH, FACP

Robert Alter, MD, weighs in on the evolution of combination therapy as the first-line standard of care for patients with metastatic clear cell RCC.

Episodes in this series

EP. 1 Trends in RCC Incidence

EP. 1 Trends in RCC Incidence

EP. 2 RCC Histologies

EP. 2 RCC Histologies

EP. 3 Risk Models and Prognostic Factors

EP. 3 Risk Models and Prognostic Factors

EP. 4 Metastatic RCC: Prognosis and Recent Advances in Care

EP. 4 Metastatic RCC: Prognosis and Recent Advances in Care

EP. 5 Biomarker Testing in RCC: Current Approaches

EP. 5 Biomarker Testing in RCC: Current Approaches

EP. 6 Biomarker Testing: Methodologies, Sample Types, and Emerging Data

EP. 6 Biomarker Testing: Methodologies, Sample Types, and Emerging Data

EP. 7 Prognostic Value of Biomarkers in RCC

EP. 7 Prognostic Value of Biomarkers in RCC

EP. 8 The Role of Genetic Mutations in Prognosis and Decision-Making

EP. 8 The Role of Genetic Mutations in Prognosis and Decision-Making

EP. 9 Comparison of Older First-Line, Single-Agent Therapies

EP. 9 Comparison of Older First-Line, Single-Agent Therapies

EP. 10 Newer First-Line Combination Therapy Options

EP. 10 Newer First-Line Combination Therapy Options

EP. 11 Evolution of Combination Therapy As The Standard of Care

EP. 11 Evolution of Combination Therapy As The Standard of Care

EP. 12 Patients Suitable for First-Line, Single-Agent Therapy and NCCN-Recommended Regimens

EP. 12 Patients Suitable for First-Line, Single-Agent Therapy and NCCN-Recommended Regimens

EP. 13 Safety and Efficacy Data: The CheckMate 214 Trial

EP. 13 Safety and Efficacy Data: The CheckMate 214 Trial

EP. 14 Safety and Efficacy Data: The JAVELIN Renal 101 Trial

EP. 14 Safety and Efficacy Data: The JAVELIN Renal 101 Trial

EP. 15 Safety and Efficacy Data: The KEYNOTE-426 Trial

EP. 15 Safety and Efficacy Data: The KEYNOTE-426 Trial

EP. 16 Safety and Efficacy Data: The CheckMate 9ER Trial

EP. 16 Safety and Efficacy Data: The CheckMate 9ER Trial

EP. 17 Safety and Efficacy Data: The CLEAR Trial

EP. 17 Safety and Efficacy Data: The CLEAR Trial

EP. 18 Common Adverse Events with Single-Agent or Combination Therapy

EP. 18 Common Adverse Events with Single-Agent or Combination Therapy

EP. 19 Balancing Treatment Efficacy with Toxicity in Metastatic RCC

EP. 19 Balancing Treatment Efficacy with Toxicity in Metastatic RCC

EP. 20 Strategies for Prevention and Management of Adverse Events

EP. 20 Strategies for Prevention and Management of Adverse Events

EP. 21 Patient-Specific Factors Impacting Treatment Choices in RCC

EP. 21 Patient-Specific Factors Impacting Treatment Choices in RCC

EP. 22 Considerations for Patient-Focused, Shared Decision-Making in RCC

EP. 22 Considerations for Patient-Focused, Shared Decision-Making in RCC

EP. 23 Clinical Pearls on Tailoring Dosing Strategies in Metastatic Kidney Cancer

EP. 23 Clinical Pearls on Tailoring Dosing Strategies in Metastatic Kidney Cancer

EP. 24 The Importance of Team-Based Management and Patient Communication

EP. 24 The Importance of Team-Based Management and Patient Communication

EP. 25 OncView™ Podcast: Safety and Efficacy of Available Treatment Options and Considerations for Patient Management in Metastatic RCC

EP. 25 OncView™ Podcast: Safety and Efficacy of Available Treatment Options and Considerations for Patient Management in Metastatic RCC

EP. 26 Reflections on Novel Targets and Emerging Regimens for RCC

EP. 26 Reflections on Novel Targets and Emerging Regimens for RCC

EP. 27 Clinical Pearls on Recent Advances and the Future of Treatment in RCC

EP. 27 Clinical Pearls on Recent Advances and the Future of Treatment in RCC

EP. 28 Recap: Safety and Efficacy of Available Treatment Options and Considerations for Management of RCC

EP. 28 Recap: Safety and Efficacy of Available Treatment Options and Considerations for Management of RCC

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C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Cases & Conversations™: Transforming AML Care—Precision Strategies, Evolving Therapies, and Clinical Insights

Gail J. Roboz, MD; Hagop Kantarjian, MD; Catherine Lai, MD, MPH; Amer Zeidan, MBBS, MHS

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Balazs Halmos, MD, MS; Enriqueta Felip, MD, PhD; Julia Rotow, MD

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

Medical Crossfire®: Harnessing the Power of Modern Therapies in Newly Diagnosed Multiple Myeloma

C. Ola Landgren, MD, PhD; Mohamad Mohty, MD, PhD; Surbhi Sidana, MD

GI Tumor Board—Applying Recent Advances in Biomarker Testing and Treatment in Metastatic Colorectal Cancer

GI Tumor Board—Applying Recent Advances in Biomarker Testing and Treatment in Metastatic Colorectal Cancer

John H. Strickler, MD; Stacey A. Cohen, MD; Aparna Parikh, MD; Kanwal P.S. Raghav, MBBS, MD

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Medical Crossfire®: Precision Medicine in Glioma Treatment — Integration of Molecular Profiling to Inform Targeted Therapies

Vinay K. Puduvalli, MD; Manmeet Ahluwalia, MD, MBA; Stephen J. Bagley, MD, MSCE; Angela Waanders, MD, MPH, MS

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

PER Tumor Board®: Applying Recent Advances to Transform the Treatment Paradigm in SCLC—Expert Perspectives on New Approvals and Emerging Strategies

Jonathan W. Goldman, MD; Percy Lee, MD, FASTRO; Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Eileen M. O’Reilly, MD; E. Gabriela Chiorean, MD, FASCO; Michael J. Pishvaian, MD, PhD; Brian Wolpin, MD, MPH

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

Medical Crossfire®: Integrating Next-Generation Endocrine Targeting Therapies to Improve Outcomes for Patients With HR+/HER2- Breast Cancer

William J. Gradishar, MD, FASCO, FACP; Laura Huppert, MD; Yuan Yuan, MD, PhD

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

Joyce O’Shaughnessy, MD; Matthew P. Goetz, MD; Hope S. Rugo, MD, FASCO

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Breaking Down the Rationale for Targeting TROP2 in TNBC

Breaking Down the Rationale for Targeting TROP2 in TNBC

Filipa Lynce, MD; Rita Nanda, MD

Cross-Disease Integration of Immunotherapy Innovations

Cross-Disease Integration of Immunotherapy Innovations

Ghassan Abou-Alfa, MD, MBA; Laura Williams Goff, MD, MSCI, MMHC, FASCO; Arndt Vogel, MD, PhD

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Virginia Kaklamani, MD, DSc; Filipa Lynce, MD; Rita Nanda, MD; Tiffany A. Traina, MD, FASCO

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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