Feature|Articles|October 8, 2026

How Would a TALAPRO-3 Approval Affect HRR-Altered Metastatic HSPC Care?

Ahead of a fourth-quarter 2026 FDA decision, TALAPRO-3 investigators outline the testing, monitoring, and sequencing steps needed to adopt the regimen.

A frontline PARP inhibitor triplet for metastatic hormone-sensitive prostate cancer (HSPC) could be available for use by the end of 2026. The FDA granted priority review to a supplemental new drug application for talazoparib (Talzenna) plus enzalutamide (Xtandi) in homologous recombination repair (HRR) gene–altered disease.1 A Prescription Drug User Fee Act (PDUFA) action date is set for the fourth quarter of 2026.

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