Opinion|Videos|August 28, 2026

Introduction and Overview of CELMoDs in Multiple Myeloma

Author(s)Joseph Mikhael, MD, Paul G. Richardson, MD, Scott Goldsmith, MD

Dr. Joseph Mikhael welcomes the audience to the Cancer Network Training Academy program and introduces Dr. Paul Richardson and Dr. Scott Goldsmith, who bring clinical and research expertise in multiple myeloma.

Episodes in this series

EP. 1 Introduction and Overview of CELMoDs in Multiple Myeloma

EP. 1 Introduction and Overview of CELMoDs in Multiple Myeloma

EP. 2 CELMoD Mechanism and Differentiation From IMiDs in Multiple Myeloma

EP. 2 CELMoD Mechanism and Differentiation From IMiDs in Multiple Myeloma

Dr. Joseph Mikhael welcomes the audience to the Cancer Network Training Academy program and introduces Dr. Paul Richardson and Dr. Scott Goldsmith, who bring clinical and research expertise in multiple myeloma. The faculty outline the program’s focus on cereblon E3 ligase modulators (CELMoDs), an emerging class of therapies in multiple myeloma. Dr. Mikhael previews the discussion, including the molecular mechanism of CELMoDs, their differentiation from established immunomodulatory drugs (IMiDs) such as lenalidomide and pomalidomide, and the evolving clinical experience with this class. The faculty will also discuss iberdomide and investigational mezigdomide, before applying the scientific and clinical concepts to two realistic multiple myeloma scenarios. The program is framed as a balanced, practical discussion intended to examine both the underlying science and emerging clinical evidence relevant to clinicians managing patients with multiple myeloma across community and academic settings.

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