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Opinion|Videos|December 6, 2024

Key Insights From the DEBBRAH and HER2CLIMB-02 Studies

Author(s)Neil M. Iyengar, MD, Odessa Williams, NP, ANCC, Dorian Nygard

Panelists discuss a brief overview of recent data on combination systemic therapies for the treatment of advanced HER2+ breast cancer, including studies such as DESTINY-Breast03, DEBBRAH, HER2CLIMB-02, and EMILIA, and they analyze which patient populations may benefit most from each therapy option based on the available data.

Episodes in this series

EP. 1 Overview of HER2 Breast Cancer

EP. 1 Overview of HER2 Breast Cancer

EP. 2 HER2+ Breast Cancer Diagnosis: Insights From Patients and Clinicians

EP. 2 HER2+ Breast Cancer Diagnosis: Insights From Patients and Clinicians

EP. 3 Coordinating Care for HER+ Breast Cancer Patients: A Multidisciplinary Approach

EP. 3 Coordinating Care for HER+ Breast Cancer Patients: A Multidisciplinary Approach

EP. 4 Multidisciplinary Care of HER2+ Breast Cancer: A Patient Perspective

EP. 4 Multidisciplinary Care of HER2+ Breast Cancer: A Patient Perspective

EP. 5 Tailoring Patient Education and Resources in HER2+ Breast Cancer

EP. 5 Tailoring Patient Education and Resources in HER2+ Breast Cancer

EP. 6 Navigating HER2+ Breast Cancer Treatment: A Patient's Journey

EP. 6 Navigating HER2+ Breast Cancer Treatment: A Patient's Journey

EP. 7 Navigating Systemic Therapy Options in HER2+ Breast Cancer

EP. 7 Navigating Systemic Therapy Options in HER2+ Breast Cancer

EP. 8 Key Insights from the HER2CLIMB Trial

EP. 8 Key Insights from the HER2CLIMB Trial

EP. 9 Key Insights From the DEBBRAH and HER2CLIMB-02 Studies

EP. 9 Key Insights From the DEBBRAH and HER2CLIMB-02 Studies

EP. 10 BRIDGET Trial: Strategies in Maintenance Therapy for HER2+ Breast Cancer with Brain Metastases

EP. 10 BRIDGET Trial: Strategies in Maintenance Therapy for HER2+ Breast Cancer with Brain Metastases

EP. 11 Preparing Patients for Treatment: Education, Administration and Adverse Effect Management in HER2+ Breast Cancer

EP. 11 Preparing Patients for Treatment: Education, Administration and Adverse Effect Management in HER2+ Breast Cancer

EP. 12 Patient Perspectives on Managing Adverse Effects from Capecitabine, Trastuzumab, and Tucatinib

EP. 12 Patient Perspectives on Managing Adverse Effects from Capecitabine, Trastuzumab, and Tucatinib

EP. 13 Comprehensive Supportive Care for Metastatic HER2+ Breast Cancer

EP. 13 Comprehensive Supportive Care for Metastatic HER2+ Breast Cancer

EP. 14 Patient Perspective: Key Aspects of Supportive Care in the HER2+ Breast Cancer Journey

EP. 14 Patient Perspective: Key Aspects of Supportive Care in the HER2+ Breast Cancer Journey

EP. 15 Future Perspectives in HER2+ Breast Cancer

EP. 15 Future Perspectives in HER2+ Breast Cancer

EP. 16 Closing Thoughts: Key Messages for Clinicians and Patients in the Treatment of HER2+ Breast Cancer

EP. 16 Closing Thoughts: Key Messages for Clinicians and Patients in the Treatment of HER2+ Breast Cancer

EP. 17 Discussing, Managing, and Treating HER2+ Breast Cancer From the Patient’s Perspective

EP. 17 Discussing, Managing, and Treating HER2+ Breast Cancer From the Patient’s Perspective

Dr Iyengar: Please provide a brief overview of other recent data in combination systemic therapies for the treatment of advanced RCC.
1. DESTINY-Breast03
2. DEBBRAH
3. HER2CLIMB-02
4. EMILIA
Given the available data, for which patient population do you prefer each therapy option and why?

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