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Opinion|Videos|November 25, 2024

Navigating Systemic Therapy Options in HER2+ Breast Cancer

Author(s)Neil M. Iyengar, MD, Odessa Williams, NP, ANCC, Dorian Nygard

Panelists discuss a high-level overview of systemic therapies for advanced HER2+ breast cancer, outlining the roles of HER2-targeted monoclonal antibodies, tyrosine kinase inhibitors (TKIs), and antibody-drug conjugates (ADCs) in treatment, as well as treatment strategies for patients with brain metastases. They also explore the shared decision-making process that informed the recommendation of the HER2CLIMB regimen.

Episodes in this series

EP. 1 Overview of HER2 Breast Cancer

EP. 1 Overview of HER2 Breast Cancer

EP. 2 HER2+ Breast Cancer Diagnosis: Insights From Patients and Clinicians

EP. 2 HER2+ Breast Cancer Diagnosis: Insights From Patients and Clinicians

EP. 3 Coordinating Care for HER+ Breast Cancer Patients: A Multidisciplinary Approach

EP. 3 Coordinating Care for HER+ Breast Cancer Patients: A Multidisciplinary Approach

EP. 4 Multidisciplinary Care of HER2+ Breast Cancer: A Patient Perspective

EP. 4 Multidisciplinary Care of HER2+ Breast Cancer: A Patient Perspective

EP. 5 Tailoring Patient Education and Resources in HER2+ Breast Cancer

EP. 5 Tailoring Patient Education and Resources in HER2+ Breast Cancer

EP. 6 Navigating HER2+ Breast Cancer Treatment: A Patient's Journey

EP. 6 Navigating HER2+ Breast Cancer Treatment: A Patient's Journey

EP. 7 Navigating Systemic Therapy Options in HER2+ Breast Cancer

EP. 7 Navigating Systemic Therapy Options in HER2+ Breast Cancer

EP. 8 Key Insights from the HER2CLIMB Trial

EP. 8 Key Insights from the HER2CLIMB Trial

EP. 9 Key Insights From the DEBBRAH and HER2CLIMB-02 Studies

EP. 9 Key Insights From the DEBBRAH and HER2CLIMB-02 Studies

EP. 10 BRIDGET Trial: Strategies in Maintenance Therapy for HER2+ Breast Cancer with Brain Metastases

EP. 10 BRIDGET Trial: Strategies in Maintenance Therapy for HER2+ Breast Cancer with Brain Metastases

EP. 11 Preparing Patients for Treatment: Education, Administration and Adverse Effect Management in HER2+ Breast Cancer

EP. 11 Preparing Patients for Treatment: Education, Administration and Adverse Effect Management in HER2+ Breast Cancer

EP. 12 Patient Perspectives on Managing Adverse Effects from Capecitabine, Trastuzumab, and Tucatinib

EP. 12 Patient Perspectives on Managing Adverse Effects from Capecitabine, Trastuzumab, and Tucatinib

EP. 13 Comprehensive Supportive Care for Metastatic HER2+ Breast Cancer

EP. 13 Comprehensive Supportive Care for Metastatic HER2+ Breast Cancer

EP. 14 Patient Perspective: Key Aspects of Supportive Care in the HER2+ Breast Cancer Journey

EP. 14 Patient Perspective: Key Aspects of Supportive Care in the HER2+ Breast Cancer Journey

EP. 15 Future Perspectives in HER2+ Breast Cancer

EP. 15 Future Perspectives in HER2+ Breast Cancer

EP. 16 Closing Thoughts: Key Messages for Clinicians and Patients in the Treatment of HER2+ Breast Cancer

EP. 16 Closing Thoughts: Key Messages for Clinicians and Patients in the Treatment of HER2+ Breast Cancer

EP. 17 Discussing, Managing, and Treating HER2+ Breast Cancer From the Patient’s Perspective

EP. 17 Discussing, Managing, and Treating HER2+ Breast Cancer From the Patient’s Perspective

Dr Iyengar: Please provide a high-level overview of the systemic therapies that you consider for advanced HER2+ breast cancer. (sSee NCCN Guidelines Version 2.2024.)
1. What is the role of HER2-targeted monoclonal antibodies, tyrosine kinase inhibitors (TKIs), and ADCs in treating advanced HER2+ breast cancer?
2. How do you typically manage treat patients with advanced HER2+ breast cancer and brain metastases?
3. Following Dorian’s evaluation, how did the shared decision-making process unfold, and what factors ultimately led you to recommend the HER2CLIMB regimen (trastuzumab [Herceptin] and + tucatinib [Tukysa] and capecitabine [Xeloda])?

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