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Opinion|Videos|January 2, 2025

Managing T-DXd-Related Toxicity and Intolerance in Later-Line HER2+ Breast Cancer

Author(s)VK Gadi, MD, PhD, Ruta Rao, MD, Jane L. Meisel, MD

Panelists discuss how managing trastuzumab deruxtecan (T-DXd)–related toxicity and intolerance in later-line HER2+ breast cancer requires close monitoring, early detection of adverse effects like interstitial lung disease, and strategic adjustments to treatment regimens for improved patient safety and outcomes.

Episodes in this series

EP. 1 Overview of Clinical Data and Treatment Selection in Later-Line HER2+ Metastatic Breast Cancer

EP. 1 Overview of Clinical Data and Treatment Selection in Later-Line HER2+ Metastatic Breast Cancer

EP. 2 Managing T-DXd-Related Toxicity and Intolerance in Later-Line HER2+ Breast Cancer

EP. 2 Managing T-DXd-Related Toxicity and Intolerance in Later-Line HER2+ Breast Cancer

EP. 3 Third-Line Approach: 54-Year-Old Patient Treated With Tucatinib-Based Regimen

EP. 3 Third-Line Approach: 54-Year-Old Patient Treated With Tucatinib-Based Regimen

EP. 4 Evolving Landscapes: Personalized Approaches in Later-Line HER2+ Treatment

EP. 4 Evolving Landscapes: Personalized Approaches in Later-Line HER2+ Treatment

EP. 5 Strategic Screening and Management of Brain Metastases in HER2+ Breast Cancer

EP. 5 Strategic Screening and Management of Brain Metastases in HER2+ Breast Cancer

EP. 6 Intracranial Efficacy Data with With Tucatinib and T-DXd in Brain Metastases

EP. 6 Intracranial Efficacy Data with With Tucatinib and T-DXd in Brain Metastases

EP. 7 Clinical Scenario: Tucatinib-Based Regimens in the Management of Brain Metastases in the 2nd-Line Metastatic Setting

EP. 7 Clinical Scenario: Tucatinib-Based Regimens in the Management of Brain Metastases in the 2nd-Line Metastatic Setting

EP. 8 Evolving Frontline Treatment Strategies and Future Directions in HER2+ Breast Cancer

EP. 8 Evolving Frontline Treatment Strategies and Future Directions in HER2+ Breast Cancer

EP. 9 Managing Brain Metastases in Patients with HER2+ Metastatic Breast Cancer

EP. 9 Managing Brain Metastases in Patients with HER2+ Metastatic Breast Cancer

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