Opinion|Videos|January 16, 2025

Navigating Post–CAR T Progression: Therapy Selection and Targeting

Author(s)Alfred Garfall, MD, Omar Nadeem, MD, Naresh Bumma, MD

Panelists discuss how sequential B-cell maturation agent (BCMA)–targeting therapies can be effective despite potential resistance patterns, with experts evaluating factors like prior response duration, alternative targets like GPRC5D or FcRH5, and patient-specific characteristics when deciding treatment sequencing after CAR T progression.

Episodes in this series

EP. 1 Brief Overview of Therapeutic Landscape for R/R MM

EP. 1 Brief Overview of Therapeutic Landscape for R/R MM

EP. 2 Comparative Outcomes: Talquetamab vs Physician's Choice in R/R Multiple Myeloma

EP. 2 Comparative Outcomes: Talquetamab vs Physician's Choice in R/R Multiple Myeloma

EP. 3 MajesTEC-1: Identifying the Optimal Patient Population for Teclistamab

EP. 3 MajesTEC-1: Identifying the Optimal Patient Population for Teclistamab

EP. 4 Elranatamab Dosing Strategies: Implications for Community Practice

EP. 4 Elranatamab Dosing Strategies: Implications for Community Practice

EP. 5 Navigating Post–CAR T Progression: Therapy Selection and Targeting

EP. 5 Navigating Post–CAR T Progression: Therapy Selection and Targeting

$EP. 6 Bispecific Therapies in Relapsed/Refractory Multiple Myeloma$

EP. 6 Bispecific Therapies in Relapsed/Refractory Multiple Myeloma

$Hematologists gathered to discuss recent updates on bispecific antibodies surrounding patients with relapsed/refractory multiple myeloma.$

EP. 7 ASH Top Takeaways of Bispecific Antibodies in R/R Multiple Myeloma

Video content above is prompted by the following:

Can BCMA-targeting bispecifics be used in patients who have received prior BCMA-targeting CAR T therapies?
When would you consider switching to a therapy hitting a different target?
Describe your approach to treatment sequencing if a patient had received CAR T-cell therapy before bispecifics and progresses.
Which therapies might you consider and why?

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