Oral Cancer Patient Presents With Pain in Mouth

Poll

A 58-year-old man treated with chemoradiotherapy for squamous cell carcinoma of the tonsil presents at follow-up with pain in the back of his mouth. What is the most likely diagnosis?

A 58-year-old man receives chemoradiotherapy as definitive management for a T3, N2b squamous cell carcinoma of the tonsil. He returns to clinic for a 6-week post-treatment follow-up visit, complaining of pain in the back of his mouth. Transoral exam is notable for the following finding (red arrow).

What is the most likely diagnosis?

A. Cancer recurrence
B. Late-onset radiation mucositis
C. Osteoradionecrosis
D. Thrush

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