Overview of Relapsed/Refractory Multiple Myeloma
The expert panel provides an overview of relapsed/refractory multiple myeloma, with a focus on current therapeutic options and unmet needs in the treatment space.
This is a video synopsis/summary of a Between the Lines series featuring Donna Catamero, ANP-BC, OCN, CCRC; Cesar Rodriguez, MD; and Saad Usmani, MD, MBA, FACP.
Usmani distinguishes between relapsed and refractory multiple myeloma. Refractory disease progresses on therapy, whereas relapsed disease recurs after a treatment-free interval of at least 2 months. Management involves selecting optimal regimens based on patient and disease factors and prior treatment tolerance. If disease is triple-class refractory, options narrow but new targets such as BCMA and GPRC5D enable chimeric antigen receptor (CAR) T-cell and bispecific antibody therapies. Two CAR T-cell products targeting BCMA are approved: idecabtagene vicleucel and ciltacabtagene autoleucel. Bispecifics include teclistamab and elranatamab.
Despite emerging treatments, unmet needs remain, including CAR T-cell accessibility, capacity for bispecific antibodies, managing renal dysfunction and frailty, post-BCMA progression, and high-risk cytogenetics.
Video synopsis is AI generated and reviewed by CancerNetwork® editorial staff.
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![“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fcancernetwork%2F70a5f0fed7009863fe30cf0740cf32014ebaf5be-2974x1660.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 "“Every patient [with multiple myeloma] should be offered CAR T before they’re offered a bispecific, with some rare exceptions,” said Barry Paul, MD.")
