(P008) The Effect of Body Mass Index on Chemoradiation Treatment Outcomes in Cervical Carcinoma

Publication
Article
OncologyOncology Vol 28 No 1S
Volume 28
Issue 1S

Obesity is a significant problem in the US, and an increase in body mass index (BMI) has an unclear effect on outcomes for patients with cervical carcinoma who receive definitive chemoradiation.

Michael C. Roach, MD, Julie K. Schwarz, MD, PhD, Perry W. Grigsby, MD, MBA; Washington University

Purpose and Background: Obesity is a significant problem in the US, and an increase in body mass index (BMI) has an unclear effect on outcomes for patients with cervical carcinoma who receive definitive chemoradiation.

Methods: This retrospective cohort included 490 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB1 or greater cervical carcinoma who received definitive treatment with chemoradiation therapy consisting of both external beam radiotherapy (EBRT) and brachytherapy between January 1998 and June 2012 at a single institution. The mean follow-up was 50 months. BMI was calculated using the National Institutes of Health online calculator. Primary outcomes were rates of overall survival (OS) and grade 3 or greater complications.

Results: Underweight patients (BMI < 18.5 kg/m2) had an inferior OS when compared with normal-weight (18.5–24.9 kg/m2) and overweight (> 24.9 kg/m2) patients (P = .04) on log-rank analysis. The 5-year OS rate was 58% (15/26) for underweight, 69% (99/143) for normal-weight, and 71% (228/321) for obese patients. Overweight patients had the lowest risk of toxicity (P = .05) on log-rank analysis. The rates of grade 3 or greater bowel or bladder toxicity were 23% for underweight (6/26), 18% for normal-weight (26/143), and 12% for overweight patients (38/321).

Conclusions: Underweight patients have inferior OS and greater complication rates when compared with normal-weight and overweight patients.

Articles in this issue

(P113) Age and Marital Status Are Associated With Choice of Mastectomy in Patients Eligible for Breast Conservation Therapy
(P112) Single-Institution Experience With Intrabeam IORT for Treatment of Early-Stage Breast Cancer
(P110) Breast Cancer Before Age 40: Current Patterns in Clinical Presentation and Local Management
(P111) Accelerated Partial-Breast Irradiation With Multicatheter High-Dose-Rate Brachytherapy: Feasibility and Results in a Private Practice Cohort
(P115) Breast Cancer Laterality Does Not Influence Overall Survival in a Large Modern Cohort: Implications for Radiation-Related Cardiac Mortality
(P117) Anatomical Variations and Radiation Technique for Breast Cancer
(P116) Bilateral Immediate DIEP Reconstruction and Postmastectomy Radiotherapy: Experience at a Tertiary Care Institution
(P118) Metadherin Overexpression Is Associated With Improved Locoregional Control After Mastectomy
(P119) Effect of Economic Environment on Use of Postlumpectomy Radiation Therapy for Stage I Breast Cancer
(P120) Immediate Versus Delayed Reconstruction After Mastectomy in the United States Medicare Breast Cancer Patient
(P121) Trend in Age and Racial Disparities in the Receipt of Postlumpectomy Radiation Therapy for Stage I Breast Cancer: 2004–2009
(P122) Streamlining Referring Physicians Orders With ‘Reflex Testing’ Significantly Decreases Time to Resolution for Abnormal Screening Mammograms
(P123) National Trends in the Local Management of Early-Stage Paget Disease of the Breast
(P124) Effect of Inhomogeneity on Cardiac and Lung Dose in Partial-Breast Irradiation Using HDR Brachytherapy
(P125) Breast Cancer Outcomes With Anthracycline-Based Chemotherapy for Residual Disease Burden After Full-Dose Neoadjuvant Chemotherapy and Surgery Followed by Radiation Treatment
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