(P130) Implication of Treatment Approach Based on Histology of Thymic Tumors

Publication
Article
OncologyOncology Vol 28 No 1S
Volume 28
Issue 1S

Thymic tumors are a rare disease and have been treated in a similar manner without convincing data. We present our institutional results of outcomes between invasive thymoma and thymic carcinoma.

Table P130

Komaki Ritsuko, MD, Xiong Wei, MD, Daniel Gomez, MD, Osamu Takahashi, MD, Pamela Allen, PhD, James D. Cox, MD; UT MD Anderson Cancer Center

Background: Thymic tumors are a rare disease and have been treated in a similar manner without convincing data. We present our institutional results of outcomes between invasive thymoma and thymic carcinoma.

Materials and Methods: Between 1964 and 2009, 125 patients with thymoma (85) or thymic carcinoma (40) were treated at UT MD Anderson Cancer Center. Treatments were follows: 50 patients (induction chemotherapy + surgery + postoperative XRT), 49 patients (surgery + radiation therapy), 16 patients (radiation only), and 10 patients (chemotherapy + XRT). The data were analyzed using Kaplan-Meier survival function. The log-rank test was used to assess survival function. Cox regression analysis was used for univariate and multivariate analysis.

Results: The median follow-up for invasive thymoma and thymic carcinoma was 79 and 46 months, respectively. Age, ethnicity, smoking history, clinical staging, Karnofsky performance score (KPS), and total dose of radiotherapy were not significantly different between the two groups. All clinical stage I or II patients, except for one inoperable patient, were found to have Masaoka stage III disease and received combined treatment. Five-year and 10-year survival rates were significantly better for the thymoma group compared with the thymic carcinoma group. Overall survival (OS) was 86% vs 60% and 59% vs 47%, respectively (P = .04). Disease-free survival (DFS) was 76% vs 58% and 72% vs 53%, respectively (P = .0326). Distant metastasis-free survival (DMFS) was 81% vs 62% and 75% vs 50%, respectively (P = .0141). Multivariate analysis showed that histology, clinical stage, and KPS were significant prognostic factors for predicting OS. Histology, ethnicity, and age were significantly correlated with DM.

Conclusions: Thymic carcinoma patients showed significantly poor OS, DFS, and DMFS compared with thymoma patients. We need to investigate more adequate systemic chemotherapy for thymic carcinoma rather than standard chemotherapy used for invasive thymoma.

Articles in this issue

(P113) Age and Marital Status Are Associated With Choice of Mastectomy in Patients Eligible for Breast Conservation Therapy
(P112) Single-Institution Experience With Intrabeam IORT for Treatment of Early-Stage Breast Cancer
(P110) Breast Cancer Before Age 40: Current Patterns in Clinical Presentation and Local Management
(P111) Accelerated Partial-Breast Irradiation With Multicatheter High-Dose-Rate Brachytherapy: Feasibility and Results in a Private Practice Cohort
(P115) Breast Cancer Laterality Does Not Influence Overall Survival in a Large Modern Cohort: Implications for Radiation-Related Cardiac Mortality
(P117) Anatomical Variations and Radiation Technique for Breast Cancer
(P116) Bilateral Immediate DIEP Reconstruction and Postmastectomy Radiotherapy: Experience at a Tertiary Care Institution
(P118) Metadherin Overexpression Is Associated With Improved Locoregional Control After Mastectomy
(P119) Effect of Economic Environment on Use of Postlumpectomy Radiation Therapy for Stage I Breast Cancer
(P120) Immediate Versus Delayed Reconstruction After Mastectomy in the United States Medicare Breast Cancer Patient
(P121) Trend in Age and Racial Disparities in the Receipt of Postlumpectomy Radiation Therapy for Stage I Breast Cancer: 2004–2009
(P122) Streamlining Referring Physicians Orders With ‘Reflex Testing’ Significantly Decreases Time to Resolution for Abnormal Screening Mammograms
(P123) National Trends in the Local Management of Early-Stage Paget Disease of the Breast
(P124) Effect of Inhomogeneity on Cardiac and Lung Dose in Partial-Breast Irradiation Using HDR Brachytherapy
(P125) Breast Cancer Outcomes With Anthracycline-Based Chemotherapy for Residual Disease Burden After Full-Dose Neoadjuvant Chemotherapy and Surgery Followed by Radiation Treatment
Recent Videos
Although accuracy remains a focus in whole-body MRI testing in patients with Li-Fraumeni syndrome, comfortable testing experiences may ease anxiety.
Subsequent testing among patients in a prospective study may affirm the ability of cfDNA sequencing to detect cancers in those with Li-Fraumeni syndrome.
cfDNA sequencing may allow for more accessible, frequent, and sensitive testing compared with standard surveillance in Li-Fraumeni syndrome.
STX-478 showed efficacy in patients with advanced solid tumors regardless of whether they had kinase domain or helical PI3K mutations.
STX-478 may avoid adverse effects associated with prior PI3K inhibitors that lack selectivity for the mutated protein vs the wild-type protein.
Phase 1 data may show the possibility of rationally designing agents that can preferentially target PI3K mutations in solid tumors.
Funding a clinical trial to further assess liquid biopsy in patients with Li-Fraumeni syndrome may help with detecting cancers early across the board.
Michael J. Hall, MD, MS, FASCO, discusses the need to reduce barriers to care for those with Li-Fraumeni syndrome, including those who live in rural areas.
Patrick Oh, MD, highlights next steps for further research in treating patients with systemic therapy in addition to radiotherapy for early-stage NSCLC.
Related Content