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Opinion|Videos|January 28, 2025

PALOMA-3: Study Design and Baseline Characteristics

Panelists discuss how PALOMA-3, a phase 3 randomized clinical trial, was designed to evaluate subcutaneous vs intravenous amivantamab, both in combination with lazertinib, in patients with refractory EGFR–mutated non–small cell lung cancer.

Episodes in this series

EP. 1 EGFR mNSCLC Front-Line: Treatment Options

EP. 1 EGFR mNSCLC Front-Line: Treatment Options

EP. 2 EGFR mNSCLC: Challenges with Treatments in this Space

EP. 2 EGFR mNSCLC: Challenges with Treatments in this Space

EP. 3 EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

EP. 3 EGFR mNSCLC Front-Line Treatment Options: Challenges and AEs

EP. 4 PALOMA-3: Study Design and Baseline Characteristics

EP. 4 PALOMA-3: Study Design and Baseline Characteristics

EP. 5 PALOMA-3: Key End Points: Pharmacokinetic and Secondary

EP. 5 PALOMA-3: Key End Points: Pharmacokinetic and Secondary

EP. 6 PALOMA-3: Key Safety Data

EP. 6 PALOMA-3: Key Safety Data

EP. 7 PALOMA-3: Managing AEs

EP. 7 PALOMA-3: Managing AEs

EP. 8 PALOMA-3: Clinical Implications

EP. 8 PALOMA-3: Clinical Implications

Newsletter

Stay up to date on recent advances in the multidisciplinary approach to cancer.

Latest CME

Indiana Oncology Society

Indiana Oncology Society

2 Sessions are Available!

Arkansas Association of Cancer Professionals

Arkansas Association of Cancer Professionals

1 Session is Available!

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Breast Cancer Tumor Board: Targeting TROP2 – Innovations in Triple-Negative Breast Cancer Treatment

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Empire State Hematology & Oncology Society (New York)

Empire State Hematology & Oncology Society (New York)

2 Sessions are Available!

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South Carolina Oncology Society

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North Carolina Oncology Association

North Carolina Oncology Association

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Breaking Down the Rationale for Targeting TROP2 in TNBC

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Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

Evaluating the Latest Data and Ongoing Trials for Novel ADC Approaches in TNBC

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Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

Expert Guidance on Frequently Asked Questions Regarding the Use of ADCs in TNBC

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Establishing the Rationale for ADC and ICI Combinations in TNBC

Establishing the Rationale for ADC and ICI Combinations in TNBC

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Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

Dissecting Clinical Trial and Real-World Data for ADCs in TNBC

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Washington State Medical Oncology Society

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Colorado Oncology Society

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Breaking Down the Latest Clinical Data for First-line Maintenance and R/R SCLC

Breaking Down the Latest Clinical Data for First-line Maintenance and R/R SCLC

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Wyoming State Oncology Society

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Broadening the Frontline—Studies Informing the Use of Immunotherapy in Hepatocellular Carcinoma

Broadening the Frontline—Studies Informing the Use of Immunotherapy in Hepatocellular Carcinoma

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Practical Considerations and Future Directions for New Treatment Strategies in SCLC

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PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

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Show Me the Data®: New and Emerging Roles for Oral SERD Therapy in the Treatment of ER+/HER2– Breast Cancer

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Expert Roundtable and Panel Discussions: Current and Future Landscape of TNBC

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Aditya Bardia, MD, MPH, FASCO; Erika P. Hamilton, MD; Tiffany A. Traina, MD, FASCO

Arizona Clinical Oncology Society

Arizona Clinical Oncology Society

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Navigating Treatment Gaps in SCLC: Relapse, Resistance, and Need for New Options

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Ready for Radioligand Therapy? Patient Selection and Sequencing Simplified

Ready for Radioligand Therapy? Patient Selection and Sequencing Simplified

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BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

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Imaging Matters: Decoding PSMA PET for Better Decision-Making

Imaging Matters: Decoding PSMA PET for Better Decision-Making

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Scott T. Tagawa, MD, MS, FACP, FASCO

Radioligand Therapy 101: The Science Behind the Strategy

Radioligand Therapy 101: The Science Behind the Strategy

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Scott T. Tagawa, MD, MS, FACP, FASCO

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

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A New Era of Targeted Therapy for Advanced NSCLC: Exploring Future Directions for Bispecific Antibodies and ADCs

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Advances in Managing EGFR-Mutant NSCLC: Applying Evidence Across the Disease Continuum

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(CME Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

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