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Opinion|Videos|April 11, 2025

PSMA PET Imaging in Prostate Cancer Staging: Guiding Initial Diagnosis and Treatment Decisions

Author(s)Jason Efstathiou, MD, DPhil, FASTRO, FACRO, Brandon Mancini, MD, MBA, FACRO , Comron Hassanzadeh, MD, MPH

Panelists discuss how PSMA PET imaging plays a crucial role in the initial staging of prostate cancer, offering superior accuracy over conventional methods. Medical professionals consider factors such as diagnostic performance, tracer availability, and patient-specific characteristics when selecting appropriate PSMA PET agents. The integration of PSMA PET findings into clinical practice has led to more precise treatment planning, potentially improving patient outcomes. Pivotal trials have demonstrated the efficacy of various PSMA PET tracers in detecting prostate cancer metastases.

Episodes in this series

4 experts in this video

EP. 1 The Evolving Role of PSMA PET in Prostate Cancer Imaging and Management

4 experts in this video

EP. 2 PSMA PET Imaging Agents: Image Quality and Diagnostic Performance

4 experts in this video

EP. 3 Selecting the Optimal PSMA PET Imaging Agent: Clinical Considerations and Data-Driven Decisions

4 experts in this video

EP. 4 Imaging Quality in Prostate Cancer: Impact on Treatment Decision-Making

4 experts in this video

EP. 5 PSMA PET Imaging in Prostate Cancer Staging: Guiding Initial Diagnosis and Treatment Decisions

4 experts in this video

EP. 6 PSMA PET Imaging in Biochemical Recurrence: Clinical Approaches and Data-Driven Decisions

4 experts in this video

EP. 7 Role of PSMA PET Imaging in Guiding Surgical Treatment Decisions in Prostate Cancer

4 experts in this video

EP. 8 Leveraging PSMA PET Imaging in Posttreatment Response Assessment: Evolving Practices and Data Insights

4 experts in this video

EP. 9 Utilizing PSMA PET Imaging in Metastatic Prostate Cancer to Guide Treatment Strategies

4 experts in this video

EP. 10 Case Discussion: Integrating PSMA PET for Focal Boost Optimization

4 experts in this video

EP. 11 Evaluating the Role of Cu-PSMA PET Imaging in Prostate Cancer

4 experts in this video

EP. 12 Key Takeaways and Future Perspectives: PSMA PET Imaging in Prostate Cancer

Video content above is prompted by the following: Briefly discuss the role of PSMA PET imaging for initial disease staging for patients with prostate cancer, considerations for selecting PSMA PET imaging agents, and how imaging guides treatment decisions in this setting.
What percentage of your newly diagnosed patients receive PSMA PET imaging, and what is your typical approach when using it in this setting?
How does PSMA PET imaging guide initial disease staging?
What do available data from pivotal trials demonstrate, and how do these findings influence your decisions in this setting?
- PSMA-PreRP – Illuccix (gallium Ga68 gozetotide) Hope et al. JAMA. 2021
- OSPREY – Pylarify (piflufolastat F18) Pienta et al. J Urol. 2021
- LIGHTHOUSE – Posluma (flotufolastat F18) Surasi et al. Eur Urol. 2023

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