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Opinion|Videos|April 4, 2025

Selecting the Optimal PSMA PET Imaging Agent: Clinical Considerations and Data-Driven Decisions

Author(s)Jason Efstathiou, MD, DPhil, FASTRO, FACRO, Brandon Mancini, MD, MBA, FACRO , Comron Hassanzadeh, MD, MPH

Panelists discuss how medical professionals select PSMA PET tracers based on factors such as diagnostic accuracy, tracer availability, patient-specific considerations, and logistical aspects such as half-life and production facilities. Fluorine-18 (^18F)–labeled tracers, such as ^18F-PSMA-1007, offer logistical advantages due to their longer half-life and higher image resolution, facilitating broader clinical application.

Episodes in this series

4 experts in this video

EP. 1 The Evolving Role of PSMA PET in Prostate Cancer Imaging and Management

4 experts in this video

EP. 2 PSMA PET Imaging Agents: Image Quality and Diagnostic Performance

4 experts in this video

EP. 3 Selecting the Optimal PSMA PET Imaging Agent: Clinical Considerations and Data-Driven Decisions

4 experts in this video

EP. 4 Imaging Quality in Prostate Cancer: Impact on Treatment Decision-Making

4 experts in this video

EP. 5 PSMA PET Imaging in Prostate Cancer Staging: Guiding Initial Diagnosis and Treatment Decisions

4 experts in this video

EP. 6 PSMA PET Imaging in Biochemical Recurrence: Clinical Approaches and Data-Driven Decisions

4 experts in this video

EP. 7 Role of PSMA PET Imaging in Guiding Surgical Treatment Decisions in Prostate Cancer

4 experts in this video

EP. 8 Leveraging PSMA PET Imaging in Posttreatment Response Assessment: Evolving Practices and Data Insights

4 experts in this video

EP. 9 Utilizing PSMA PET Imaging in Metastatic Prostate Cancer to Guide Treatment Strategies

4 experts in this video

EP. 10 Case Discussion: Integrating PSMA PET for Focal Boost Optimization

4 experts in this video

EP. 11 Evaluating the Role of Cu-PSMA PET Imaging in Prostate Cancer

4 experts in this video

EP. 12 Key Takeaways and Future Perspectives: PSMA PET Imaging in Prostate Cancer

Video content above is prompted by the following:

What factors do you consider when selecting a PSMA PET tracer for a particular patient or clinical scenario?
When might you opt for F18 vs Ga58, and how do available data inform your decision?
- Meta-analysis F18 vs G68 (Huang et al. Prostate Cancer. 2023)
- Do you still see a role for Axumin? If so, in what scenarios?

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