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Opinion|Videos|March 10, 2025

Tailoring Therapy: Patient-Specific Decision-Making in Relapsed DLBCL

Author(s)Krish Patel, MD, Saurabh Dahiya, MD, FACP, Nathan Denlinger, DO, MS

Panelists discuss the optimal timing of chimeric antigen receptor T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma (DLBCL), which requires careful evaluation of patient fitness, disease burden, prior treatment response, and logistical factors. Key considerations include performance status, comorbidities, disease aggressiveness, and the availability of bridging therapy. Treatment decisions should be individualized based on patient-specific risk factors, prior therapy outcomes, and care goals while balancing the potential benefits and risks across different lines of treatment.

Episodes in this series

5 experts in this video

EP. 1 DLBCL in Focus: Transforming Outcomes With CAR T Therapy

5 experts in this video

EP. 2 Beyond Salvage: When to Move to CAR T in Relapsed DLBCL

5 experts in this video

EP. 3 Tailoring Therapy: Patient-Specific Decision-Making in Relapsed DLBCL

5 experts in this video

EP. 4 TRANSFORM and ZUMA-7: A Discussion on Efficacy and Safety of CAR T in R/R DLBCL

5 experts in this video

EP. 5 CAR T in the Real World: Clinician Perspectives on Outcomes, Toxicity, and Patient Management

5 experts in this video

EP. 6 Rethinking CAR T Timing: Insights on CAR T Efficacy and Patient Selection

5 experts in this video

EP. 7 Personalizing CAR T: Making the Right Call for Each Patient

5 experts in this video

EP. 8 Auto-SCT or CAR T? A Case-Based Discussion in Relapsed DLBCL

5 experts in this video

EP. 9 Transplant-Eligible, CAR T Considered: How Do We Decide?

5 experts in this video

EP. 10 CAR T in High-Risk DLBCL: Making the Right Choice in Aggressive Disease

5 experts in this video

EP. 11 The Future of DLBCL: Innovations in Therapy and Patient Care

Video content above is prompted by the following:

What factors should be considered when determining the optimal timing and patient selection for advanced therapies like chimeric antigen receptor T-cell therapy in relapsed/refractory DLBCL?
How might you consider treatment decisions for patients across different risk profiles and lines of therapy?

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