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Opinion|Videos|March 17, 2025

CAR T in the Real World: Clinician Perspectives on Outcomes, Toxicity, and Patient Management

Author(s)Krish Patel, MD, Saurabh Dahiya, MD, FACP, Nathan Denlinger, DO, MS

Panelists discuss the comparison between clinical trial results and real-world outcomes for chimeric antigen receptor T-cell (CAR T) therapies like liso-cel and axi-cel. Clinical trials have shown promising efficacy and manageable safety profiles for both therapies in treating certain blood cancers. However, real-world evidence continues to emerge through ongoing clinical use and registry data collection.

Episodes in this series

5 experts in this video

EP. 1 DLBCL in Focus: Transforming Outcomes With CAR T Therapy

5 experts in this video

EP. 2 Beyond Salvage: When to Move to CAR T in Relapsed DLBCL

5 experts in this video

EP. 3 Tailoring Therapy: Patient-Specific Decision-Making in Relapsed DLBCL

5 experts in this video

EP. 4 TRANSFORM and ZUMA-7: A Discussion on Efficacy and Safety of CAR T in R/R DLBCL

5 experts in this video

EP. 5 CAR T in the Real World: Clinician Perspectives on Outcomes, Toxicity, and Patient Management

5 experts in this video

EP. 6 Rethinking CAR T Timing: Insights on CAR T Efficacy and Patient Selection

5 experts in this video

EP. 7 Personalizing CAR T: Making the Right Call for Each Patient

5 experts in this video

EP. 8 Auto-SCT or CAR T? A Case-Based Discussion in Relapsed DLBCL

5 experts in this video

EP. 9 Transplant-Eligible, CAR T Considered: How Do We Decide?

5 experts in this video

EP. 10 CAR T in High-Risk DLBCL: Making the Right Choice in Aggressive Disease

5 experts in this video

EP. 11 The Future of DLBCL: Innovations in Therapy and Patient Care

Video content above is prompted by the following:

How do the efficacy and safety outcomes of liso-cel and axi-cel in clinical trials compare to what you have observed in real-world practice?
Are there specific patient populations or clinical scenarios where you find the trial data align—or diverge—from real-world experiences with CAR T therapy?

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