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Opinion|Videos|March 31, 2025

CAR T in High-Risk DLBCL: Making the Right Choice in Aggressive Disease

Author(s)Krish Patel, MD, Saurabh Dahiya, MD, FACP, Nathan Denlinger, DO, MS

Panelists discuss that when selecting a chimeric antigen receptor T-cell (CAR T) product for a patient with an aggressive clinical course and eligibility for cellular therapy, key considerations include urgency, toxicity risks, and efficacy. Factors such as time to manufacture, cytokine release syndrome/immune effector cell–associated neurotoxicity syndrome rates, long-term remission data, and antigen specificity guide decision-making.

Episodes in this series

5 experts in this video

EP. 1 DLBCL in Focus: Transforming Outcomes With CAR T Therapy

5 experts in this video

EP. 2 Beyond Salvage: When to Move to CAR T in Relapsed DLBCL

5 experts in this video

EP. 3 Tailoring Therapy: Patient-Specific Decision-Making in Relapsed DLBCL

5 experts in this video

EP. 4 TRANSFORM and ZUMA-7: A Discussion on Efficacy and Safety of CAR T in R/R DLBCL

5 experts in this video

EP. 5 CAR T in the Real World: Clinician Perspectives on Outcomes, Toxicity, and Patient Management

5 experts in this video

EP. 6 Rethinking CAR T Timing: Insights on CAR T Efficacy and Patient Selection

5 experts in this video

EP. 7 Personalizing CAR T: Making the Right Call for Each Patient

5 experts in this video

EP. 8 Auto-SCT or CAR T? A Case-Based Discussion in Relapsed DLBCL

5 experts in this video

EP. 9 Transplant-Eligible, CAR T Considered: How Do We Decide?

5 experts in this video

EP. 10 CAR T in High-Risk DLBCL: Making the Right Choice in Aggressive Disease

5 experts in this video

EP. 11 The Future of DLBCL: Innovations in Therapy and Patient Care

Video content above is prompted by the following:

Given the aggressive clinical course and patient eligibility for cellular therapy and considering the urgency, toxicity risks, and efficacy profiles, what factors would guide your choice between available CAR T products?

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