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Opinion|Videos|March 31, 2025

Transplant-Eligible, CAR T Considered: How Do We Decide?

Author(s)Krish Patel, MD, Saurabh Dahiya, MD, FACP, Nathan Denlinger, DO, MS

Panelists discuss how, when selecting among chimeric antigen receptor T-cell (CAR T) therapies, medical professionals typically consider several key factors: the specific cancer type and its CD19/BCMA expression, FDA-approved indications for each therapy, the patient’s prior treatments and response history, the therapy’s documented efficacy and safety profile, manufacturing time and availability, and center-specific experience with different products. Patient-specific factors like comorbidities and disease burden also influence the decision.

Episodes in this series

5 experts in this video

EP. 1 DLBCL in Focus: Transforming Outcomes With CAR T Therapy

5 experts in this video

EP. 2 Beyond Salvage: When to Move to CAR T in Relapsed DLBCL

5 experts in this video

EP. 3 Tailoring Therapy: Patient-Specific Decision-Making in Relapsed DLBCL

5 experts in this video

EP. 4 TRANSFORM and ZUMA-7: A Discussion on Efficacy and Safety of CAR T in R/R DLBCL

5 experts in this video

EP. 5 CAR T in the Real World: Clinician Perspectives on Outcomes, Toxicity, and Patient Management

5 experts in this video

EP. 6 Rethinking CAR T Timing: Insights on CAR T Efficacy and Patient Selection

5 experts in this video

EP. 7 Personalizing CAR T: Making the Right Call for Each Patient

5 experts in this video

EP. 8 Auto-SCT or CAR T? A Case-Based Discussion in Relapsed DLBCL

5 experts in this video

EP. 9 Transplant-Eligible, CAR T Considered: How Do We Decide?

5 experts in this video

EP. 10 CAR T in High-Risk DLBCL: Making the Right Choice in Aggressive Disease

5 experts in this video

EP. 11 The Future of DLBCL: Innovations in Therapy and Patient Care

Video content above is prompted by the following:

If you proceed with CAR T, how would you approach selection among the available CAR T therapies?

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PER Resource Center: Integrating Novel Approaches in TNBC – New Avenues for TROP2-Targeting ADCs and Beyond – Nursing

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

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Yana G. Najjar, MD; Sapna Patel, MD

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

(Pharmacist Track) Antibody–Drug Conjugates in Oncology: The Essentials of AE Management for Better Patient Outcomes

Michelle L. Taylor, ANP-BC; Emely Alfaro, DNP, RN, CNS, OCN; Paige Griffith, CRNP; Beth Sandy, MSN, CRNP, FAPO

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