XELOX Compares Favorably With FOLFOX4 in Adjuvant Therapy for Colorectal Cancer

Publication
Article
Oncology NEWS InternationalOncology NEWS International Vol 14 No 8
Volume 14
Issue 8

ORLANDO-In first-line metastaticcolorectal cancer, capecitabine(Xeloda) is better tolerated than fluorouracil/leucovorin (5-FU/LV), and

ORLANDO-In first-line metastaticcolorectal cancer, capecitabine(Xeloda) is better tolerated than fluorouracil/leucovorin (5-FU/LV), andthe addition of capecitabine to oxaliplatin(Eloxatin)(XELOX) is both effectiveand tolerated, Hans-JoachimSchmoll, MD, PhD, said (abstract3523). Dr. Schmoll reported early safetyfindings from a phase III trial ofXELOX vs bolus 5-FU/LV as adjuvanttherapy for patients with stage III coloncancer."In the MOSAIC trial, oxaliplatin+ 5-FU/LV (FOLFOX4) resulted insuperior disease-free survival comparedwith 5-FU/LV and has recentlybeen approved for adjuvant therapy.As in metastatic colorectal cancer,capecitabine should be considered asan alternative to 5-FU/LV in combinationwith oxaliplatin in the adjuvantsetting. Therefore, we comparedthe safety and efficacy of XELOX withthose of bolus 5-FU/LV (the standardregimen at the start of the study) asadjuvant therapy for stage III coloncancer," Dr. Schmoll said.This ongoing study enrolled 1,886patients with resected stage III coloncancer. Patients were randomized toreceive XELOX (capecitabine: 1,000mg/m2 twice daily on days 1-14 +oxaliplatin: 130 mg/m2 on day 1, every3 weeks for eight cycles) or IV bolus 5-FU/LV (Mayo Clinic regimen: LV-20mg/m2 + 5-FU-425 mg/m2 on days 1-5, every 4 weeks for six cycles; orRoswell Park regimen: LV-500 mg/m2+ 5-FU-500 mg/m2 on day 1, for weeks1-6 in four 8-week cycles).Reduced Rate of FebrileNeutropeniaA total of 1,719 patients were evaluablefor safety. "There was a similarrate of related adverse events withXELOX and 5-FU/LV. There was lessgrade 3/4 stomatitis (1% vs 8%), neutropenia(8% vs 15%), and febrile neutropenia(< 1% vs 4%) with XELOXthan with 5-FU/LV. There was morefrequent grade 3 hand-foot syndrome(5% vs 1%) and grade 3/4 thrombocytopenia(5% vs 1%) with XELOX thanwith 5-FU/LV. Fifty-four percent ofXELOX patients and 45% of 5-FU/LVpatients experienced treatment-relatedgrade 3/4 adverse events. Sixty-dayall-cause mortality was 1% on botharms," Dr. Schmoll said."The lower rate of neutropenia withXELOX led to a reduced rate of grade3/4 febrile neutropenia," Dr. Schmollsaid.Dr. Schmoll and investigators concludedthat the safety data from thistrial indicate that XELOX is feasible inadjuvant treatment of colon cancerand compares favorably with FOLFOX4."XELOX appears to cause lessmyelosuppression and stomatitis butmore skin and neurosensory toxicitiesthan 5-FU/LV. XELOX has now beenincorporated in the three-arm AVANTadjuvant trial (FOLFOX4 vs FOLFOX4+ bevacizumab [Avastin] vs XELOX +bevacizumab)," Dr. Schmoll said. Efficacyresults are expected in 2007.

Related Videos
Immunotherapy may be an “elegant” method of managing colorectal cancer, says Gregory Charak, MD.
Administering neoadjuvant therapy to patients with colorectal cancer may help surgical oncologists attain a negative-margin resection.
Increasing screening for younger individuals who are at risk of colorectal cancer may help mitigate the rising early incidence of this disease.
Laparoscopy may reduce the degree of pain or length of hospital stay compared with open surgery for patients with colorectal cancer.
Rahul Gosain, MD; Sam Klempner, MD; and Rohit Gosain, MD, presenting slides
Rahul Gosain, MD; Sam Klempner, MD; and Rohit Gosain, MD, presenting slides
Rahul Gosain, MD; Sam Klempner, MD; and Rohit Gosain, MD, presenting slides
Rahul Gosain, MD; Sam Klempner, MD; and Rohit Gosain, MD, presenting slides
Rahul Gosain, MD; Sam Klempner, MD; and Rohit Gosain, MD, presenting slides
Tailoring neoadjuvant therapy regimens for patients with mismatch repair deficient gastroesophageal cancer represents a future step in terms of research.