Around the Practice: Identifying High-Risk Patients With Advanced Cutaneous Squamous Cell Carcinoma and Optimizing the Multidisciplinary Treatment Journey

EP. 1: Introduction and Current Landscape of Cutaneous Squamous Cell Carcinoma
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Learn how clinicians spot aggressive cutaneous squamous cell carcinoma and when multidisciplinary care and immunotherapy improve outcomes.

EP. 2: Multidisciplinary Referral for Patients with cSCC and Care Transitions
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Learn when high-risk skin SCC needs early oncology referrals, imaging, and coordinated tumor-board care to avoid delays and improve outcomes.

EP. 3: When to Consider Systemic Therapy for cSCC
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Learn red flags for advanced cutaneous SCC and how PD‑1/PD‑L1 immunotherapy offers durable responses, reshaping treatment beyond surgery.

EP. 4: Checkpoint Inhibitor Evidence: EMPOWER and C-POST Trials
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD C-POST shows adjuvant cemiplimab cuts recurrence risk in high‑risk cutaneous SCC after surgery and radiation, reshaping multidisciplinary care.

EP. 5: Real-World Data and Neoadjuvant Use in cSCC
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Real-world cemiplimab data and neoadjuvant results show strong responses in high-risk cutaneous SCC, guiding treatment for frail, complex patients.

EP. 6: Clinical Scenario 1: High-Risk Adjuvant Setting in cSCC Treatment
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Expert panel explains extremely high-risk cutaneous SCC after surgery and radiation, and why adjuvant cemiplimab may curb recurrence.

EP. 7: Monitoring the No Evidence of Disease Patient and Multidisciplinary Collaboration
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Dr. Zager outlines a monitoring strategy for the Case 1 patient who is NED following surgery and radiation.

EP. 8: Toxicity Management and Quality of Life
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Dr. Park addresses management of low-grade immune-related adverse events (irAEs), the most common toxicities encountered with checkpoint inhibitors, including dermatitis, pruritus, and GI symptoms.

EP. 9: Clinical Scenario 2: Locally Advanced cSCC With CLL and Comorbidities
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Recurrent facial squamous cell cancer with CLL challenges surgery and radiation; experts weigh immunotherapy, cemiplimab data, and patient goals.

EP. 10: irAE Management in Detail and Post-Progression Options
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Learn how to spot and treat cemiplimab immune side effects early, and why multidisciplinary teams improve advanced cutaneous SCC outcomes.

EP. 11: Biomarkers and Immunocompromised Patients
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Explores why PD-L1 falls short in skin SCC and how TMB and transplant-safe immunotherapy may shape personalized care.

EP. 12: Future Directions and Key Takeaways in the Field of cSCC
ByGaurav Singh, MPH, FACMS,Soo Park,Jonathan Schoenfeld, MD, MPhil, MPH,Vernon K. Sondak, MD,Jonathan S. Zager, MD Explore new cutaneous SCC strategies: neoadjuvant PD-1, combo regimens, intralesional RP1, and early multidisciplinary referral.