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Breast Cancer

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WASHINGTON-A definite link exists between mammography screening and lessened breast cancer mortality, but black women do not take full advantage of cancer screening, according to Janice S. Emerson, research associate, Center for Health Research, Tennessee State University, Nashville. Speaking at the American Psychological Association Conference on Enhancing Outcomes in Women’s Health, she presented findings from an HCFA-funded project, led by Dr. Baqar A. Husaini.

Recruitment for a challenging breast cancer trial has begun at sites in more than 40 countries. It is hoped that more than 3,000 patients from approximately 600 sites will participate in a study designed to determine whether earlier use of trastuzumab (Herceptin) increases disease-free survival in women with early breast cancer.

ROCKVILLE, Maryland-Members of the Oncologic Drugs Advisory Committee (ODAC) have unanimously recommended that the Food and Drug Administration approve Zometa (zoledronic acid for injection, Novartis) for the treatment of bone metastases in patients with multiple myeloma and breast cancer, prostate cancer, lung cancer, and other solid tumors.

SAN ANTONIO-A multicenter phase II study conducted in France has shown that epirubicin (Ellence) and docetaxel (Taxotere) (ET) offer better results as first-line chemotherapy than fluorouracil (5-FU), epirubicin, and cyclophosphamide (FEC) among patients with metastatic breast cancer.

CHICAGO-Brachytherapy devices that deliver radiation therapy directly to the lumpectomy site drastically reduce the time needed for radiotherapy after surgery for early-stage breast cancer, according to two studies presented at the 87th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA).

ORLANDO-Treatments credited with improving 5-year survival rates for patients with childhood Hodgkin’s disease may lead to an increased risk of leukemia, breast cancer, and other neoplasms years later, according to a study by the Late Effects Study Group (LESG) presented at the American Society of Hematology annual meeting (abstract 3198).

Despite a tight proposed domestic budget for fiscal 2003, President Bush wants to increase spending on the National Breast and Cervical Cancer Early Detection Program administered by the Centers for Disease Control and Prevention (CDC).

BETHESDA, Maryland-The scientific conflict about whether mammography saves lives has been reignited by the decision by an independent advisory committee to rescind its support for such screening and to emphasize the uncertainty of the evidence supporting it.

SAN ANTONIO-A retrospective study presented at the 24th Annual San Antonio Breast Cancer Symposium (abstract 18) has shown that breast cancer patients selected for treatment with trastuzumab (Herceptin) combination therapy on the basis of HER-2 gene amplification by fluorescent in situ hybridization (FISH) may have improved clinical benefits.

SAN ANTONIO-Tamoxifen (Nolvadex) therapy not only prevents breast cancer but also benign breast disease in high-risk women, according to a study by the National Surgical Adjuvant Breast and Bowel Project (NSABP) presented at the 24th San Antonio Breast Cancer Symposium (abstract 7). Elizabeth Tan-Chiu, MD, of the NSABP, reported the findings.

SAN FRANCISCO-Time to failure, time to distant metastasis, and time to death in patients with early-stage breast cancer are not influenced by the order in which chemotherapy and radiotherapy are initiated, according to updated results of a study presented at the 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO plenary 4). These latest long-term results are in contrast to earlier findings from the study.

WILMINGTON, Delaware-The US Food and Drug Administration (FDA) has granted fast track designation for AstraZeneca’s Arimidex (anastrozole) for the adjuvant treatment of postmenopausal women with early-stage breast cancer. The decision followed the release of data from the ATAC (Arimidex, Tamoxifen, Alone or in Combination) study at the 24th San Antonio Breast Cancer Symposium.

Surgery is still the most important treatment for solid tumors, regardless of the age of the patient. In this article, we discuss the physiology of aging as it relates to risk assessment in the elderly surgical oncology patient. A brief review of the role of surgery in the treatment of breast, colorectal, pancreatic, and gastric cancer is provided, because these solid tumors primarily affect elderly patients.

SAN ANTONIO-In the largest breast cancer trial ever conducted, anastrozole (Arimidex) emerged the winner in a head-to-head comparison with tamoxifen (Nolvadex) in early-stage breast cancer. The impressive results, in both efficacy and tolerability, were reported at the 24th Annual San Antonio Breast Cancer Symposium (abstract 8).

CHICAGO-The overwhelming majority of women with invasive breast cancer who are node-negative, both those with positive and negative estrogen receptors, routinely receive chemotherapy today. "But it’s worthwhile to step back and ask

CHICAGO-The role of endocrine therapy in breast cancer is still evolving, with about half a dozen agents contending as players in the metastatic, adjuvant, and chemoprevention settings. At the Lynn Sage Breast Cancer Conference, William