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Novel Therapy Yields Anti-Tumor Activity in KRAS G12C–Mutated CRC
Novel Therapy Yields Anti-Tumor Activity in KRAS G12C–Mutated CRC

May 31st 2025

As a single agent or in combination, MK-1084 showed promising efficacy and safety results for patients with KRAS G12C–mutated CRC.

Emergent alteration patterns were similarly diverse across treatment arms in the phase 3 CodeBreaK 300 study.
Genomic Alterations May Cause Resistance to Sotorasib KRAS G12C+ CRC Combo

May 31st 2025

Nivolumab/Ipilimumab Sustain Benefit Vs Chemo or Nivolumab in MSI-H/dMMR CRC
Nivolumab/Ipilimumab Sustain Benefit Vs Chemo or Nivolumab in MSI-H/dMMR CRC

May 31st 2025

Anlotinib/chemotherapy showed comparable efficacy vs bevacizumab/chemotherapy in patients with RAS/BRAF wild-type metastatic colorectal cancer.
Anlotinib Shows Noninferiority to Bevacizumab in RAS/BRAF Wild-Type mCRC

May 31st 2025

ctDNA-Informed Treatment Doesn’t Impact RFS in Stage III Colon Cancer
ctDNA-Informed Treatment Doesn’t Impact RFS in Stage III Colon Cancer

May 31st 2025