Lung Cancer

A computer modeling analysis studied the use of NGS and its costs in patients with metastatic non–small-cell lung cancer.

A new study identified several T-cell antigens that are shared between tumor tissue and skin in a cohort of patients with non–small-cell lung cancer who were treated with anti–PD-1 therapy.

In this case report, we present a non-Hodgkin lymphoma survivor who was incidentally found to have non–small-cell lung cancer 30 years after undergoing treatment that included mantle radiation. We discuss the treatment-related risk factors for lung cancer in this population and potential implications for long-term follow-up.

In this installment of Oncology Drug Updates, updates to FDA approvals for pembrolizumab in the treatment of lung cancer and RCC are highlighted.

The findings further validate the initial 2015 findings that a five-fraction SBRT schedule is appropriate for patients with centrally located NSCLC.

In this article, important concepts in the molecular testing of non–small-cell lung cancer are highlighted.

A study looked at whether a lung cancer risk prediction model could identify patients at high risk for lung cancer who could receive less frequent low-dose CT screening.

Cancer Network spoke with Lecia V. Sequist, MD, MPH, about the TATTON study, which tested the combination of osimertinib and savolitinib in previously treated non–small-cell lung cancer patients.

A pooled analysis of two trials presented at the AACR Annual Meeting looked at the use of pembrolizumab in patients with heavily pretreated extensive small-cell lung cancer.

The revised version focuses on the first-line use of immunotherapy and the measurement of tumor cells expressing PD-L1.

In this article, we review the new developments in neoadjuvant therapy for lung cancer.

Researchers' findings on the efficacy of a liquid biopsy test called Guardant360 vs standard tissue biopsies will be presented at AACR 2019.

A trial showed that tumor mutational burden may be effective as a biomarker in patients treated with immunotherapy.

Researchers studied the combination of a cellular vaccine known as HS-110 and nivolumab in an early-phase trial of patients with advanced non–small-cell lung cancer.

Results of the 2-year follow-up analysis of the pivotal KEYNOTE-024 trial were recently published in the Journal of Clinical Oncology.

Two new studies found that targeting the cyclin-dependent kinases 4/6 exposed a vulnerability in SMARCA4-deficient cancers.

A set of simple interventions succeeded in reducing disparities in lung cancer care between black and white patients across five cancer centers.

The large precision medicine trial known as Lung-MAP has announced it will expand to patients with all non–small-cell lung cancers, accounting for as many as 85% of all lung cancer diagnoses in the US.

The results, described by an expert as “very interesting” and a “a bit surprising," focused on the impact of autoimmune antibodies on anti–PD-1 therapy.

The phase III CONVERT trial compared twice-daily vs once-daily concurrent chemoradiotherapy in elderly patients with limited-stage small-cell lung cancer.

A surprisingly low percentage of Medicare enrollees who undergo low-dose CT screening for lung cancer participate in a shared decision-making session prior to the screening.

Researchers investigated whether first-line chemotherapy improved overall survival in NSCLC patients with severe to very severe COPD.

Researchers evaluated the survival benefit of adding pembrolizumab to chemotherapy with carboplatin plus paclitaxel or nab–paclitaxel compared with chemotherapy alone.

The long-term results from an analysis of two phase II studies confirmed the role of osimertinib in the treatment of T790M mutation–positive advanced non–small-cell lung cancer.

Researchers found that patients with stage I/II lung cancer have relatively long-term survival when treated with chemoradiotherapy, calling into question the practice of combining these patients with stage III patients.