Oncology Vol 28 No 9

Waiting for a Miracle

September 15, 2014

I was recently consulted concerning a patient in the ICU at my hospital with advanced breast cancer, but I soon realized there were much larger issues at stake. This woman is in her 50s and was diagnosed approximately 1 year ago with metastatic triple-negative breast cancer.

Routine Use of Maintenance Therapy in Follicular Lymphoma: Examine the Rationale for Maintenance Use Before Uniformly Adopting a Strategy

September 15, 2014

While definitions of follicular lymphoma maintenance therapy in clinical trials and clinical practice have been somewhat variable, ideally maintenance therapy would be limited to patients in complete remission or with minimal residual disease following initial therapy

Heterogeneity and Cancer

September 15, 2014

Cancer heterogeneity, long recognized as an important clinical determinant of patient outcomes, was poorly understood at a molecular level. Genomic studies have significantly improved our understanding of heterogeneity, and have pointed to ways in which heterogeneity might be understood and defeated for therapeutic effect.

Neuroendocrine Tumors: Answers-and Questions

September 15, 2014

The relative abundance of new data on the biological underpinnings of neuroendocrine tumors, combined with clinical trial data supporting new treatment options, is a clear sign of progress. Yet, as is so often the case, these recent studies have generated a multitude of new and different questions.

Chemobrain: Is It Time to Initiate Guidelines for Assessment and Management?

September 15, 2014

Cognitive dysfunction during and following treatment for cancer, often referred to as “chemobrain,” is an adverse effect of cancer treatment that may interfere with patients’ ability to resume their precancer lifestyle, with subsequently reduced quality of life.

Cancer- and Treatment-Related Cognitive Changes: What Can We Do Now? What Lies Ahead?

September 15, 2014

Much of the existing research into the phenomenon commonly referred to as “chemobrain” has been descriptive, and we know enough now to identify some patients at risk for cognitive changes after a diagnosis of cancer.

Tumor Heterogeneity: The Lernaean Hydra of Oncology?

September 15, 2014

Intratumor heterogeneity is one of the biggest challenges in cancer diagnosis and treatment. Despite morphologic and clinical recognition of tumor heterogeneity, an understanding of it at a molecular level has only begun to emerge in recent years.

Tumor Heterogeneity and Implications for Clinical Practice

September 15, 2014

The issue of tumor heterogeneity is real, and it is present on several different levels. Without question, the presence of tumor heterogeneity has important clinical implications, and at this time, it represents a significant challenge to the success of cancer therapy.

What Next? Choosing Second-Line Therapy in Progressive Renal Cell Carcinoma

September 15, 2014

A 71-year-old woman presented with back pain and was incidentally found to have a left upper pole renal mass. She underwent left open partial nephrectomy; the pathology results revealed a 2.2-cm clear-cell renal cell carcinoma (RCC) with negative margins and a Fuhrman nuclear grade of 2.