Oncology Vol 29 No 2

The Different Faces of Disseminated Intravascular Coagulation in Solid Tumors: How to Identify and Manage

February 15, 2015

“Treat the underlying cause” has been the classic mantra for the treatment of disseminated intravascular coagulation. Whenever feasible in disseminated intravascular coagulation associated with solid tumors, this principle appears to hold good.

Disseminated Intravascular Coagulation in Patients With Solid Tumors

February 15, 2015

This review summarizes the published data regarding the association of disseminated intravascular coagulation (DIC) with solid tumors, the laboratory diagnosis of DIC, the clinical presentation and types of tumors typically seen with DIC, and the pathophysiologic mechanisms involved; it also offers suggestions for management of DIC in patients with solid tumors.

The Future of Systemic Therapy of Melanoma: Combinations, Predictive Biomarkers

February 15, 2015

While the last several decades saw a lack of progress in treatment outcomes in this setting, the outlook has recently changed dramatically, driven by a deepening understanding of melanoma biology and host immunology.

Systemic Therapy of Metastatic Melanoma: On the Road to Cure

February 15, 2015

In this article, we summarize the systemic therapies now available for melanoma, with a focus on the recently approved agents for cutaneous melanoma; discuss important considerations in selecting a treatment from the available options; and highlight some of the promising investigational approaches for this disease.