Videos

Boris M. Kiselev, MD, explores evidence-based interventions for managing cancer-related anxiety and depression.

Experts discuss how postoperative surveillance after colorectal cancer surgery is increasingly personalized by integrating pathologic staging, surgical quality, and ctDNA testing to adjust monitoring intensity, with higher-risk or uncertain cases receiving more aggressive follow-up to optimize early detection and intervention.

Panelists discuss how current chimeric antigen receptor (CAR) T therapies for early relapsed/refractory multiple myeloma (R/R MM) include both ciltacabtagene autoleucel (cilta-cel) and idecabtagene vicleucel (ide-cel), both targeting the B-cell maturation antigen (BCMA), with cilta-cel showing superior outcomes in second-line patients compared with ide-cel’s performance in third- and fourth-line settings. They also emphasize that regardless of which CAR T is used, both significantly outperform standard-of-care treatments. Looking toward the future, emerging CAR T therapies are targeting new antigens like GPRC5D on myeloma cells, with phase 2 clinical trials already enrolling patients whose disease returned after initial CAR T treatment, offering hope for sequential CAR T approaches as the field moves toward increasingly immunotherapy-focused treatment strategies.

Panelists discuss how the CARTITUDE-4 clinical trial demonstrated that ciltacabtagene autoleucel (cilta-cel) chimeric antigen receptor (CAR) T-cell therapy significantly outperformed standard-of-care treatments in patients with early relapsed/refractory multiple myeloma (R/R MM), showing higher response rates, complete remission rates, and deeper minimal residual disease (MRD)-negative remissions while also providing superior quality of life with treatment breaks vs continuous therapy requirements, and, most importantly, becoming the first therapy in this patient population to demonstrate improved overall survival and actually prolong life.

Experts discuss the pivotal role of ctDNA in postoperative colorectal cancer care, using it alongside pathology and staging to personalize recurrence risk assessment and guide adjuvant therapy decisions, particularly in nuanced cases where ctDNA results and clinical risk factors may not align.

Boris M. Kiselev, MD, discusses the essential role of psycho-oncology in addressing patient distress, improving treatment adherence, and supporting long-term survivorship.

Declan Walsh, MD, highlighted the need for nutrition research to enhance oncology care.

Being proactive and quickly identifying when a patient may need the supportive care team is the best way to integrate this field into whole-person care.

An expert explains that while bispecific antibodies show strong efficacy in relapsed/refractory multiple myeloma, optimizing their safety—through step-up dosing, infection prophylaxis, immunoglobulin support, and early symptom management—is essential to minimizing toxicity and expanding access to this promising treatment class.

Tycel Phillips, MD, highlighted the need for new therapies for patients with MCL who have experienced relapse on previous lines of treatment.

Tycel Phillips, MD, spoke about the impact the glofitamab CRL had on the landscape of bispecifics in lymphoma.

Peter Martin, MD, discusses the complexities of treating relapsed MCL after treatment with a BTK inhibitor.

Panelists discuss how to manage slow FLAIR progression by initiating IDH inhibitor therapy, emphasizing the importance of setting patient expectations about tumor volume reduction and addressing special considerations for patients of childbearing age.

Panelists discuss how to counsel a 38-year-old patient with excellent surgical outcome about treatment options, weighing the benefits of early IDH inhibitor therapy against watchful waiting while considering individual patient factors and goals.

Peter Martin, MD, discusses the shifting paradigm for treating fit, transplant-eligible patients with MCL.

Historical standards for H3 K27M–mutant diffuse midline glioma treatment may harm healthy central nervous system cells, according to Ashley L. Sumrall, MD.

Experts discuss how initial postoperative visits after colorectal cancer surgery integrate pathology review, recurrence risk assessment, and timely ctDNA testing to personalize prognosis and guide surveillance, emphasizing the importance of surgical quality indicators and molecular tools in shaping follow-up care.

Experts discuss how postsurgical surveillance for colorectal cancer varies by setting, with multidisciplinary teams leading coordinated care in academic centers, whereas surgeons in rural or resource-limited areas often take on expanded roles to ensure follow-up and monitoring are not compromised.

Panelists discuss how patients typically respond well to chimeric antigen receptor (CAR) T-cell therapy with manageable adverse effects (AEs), including expected cytokine release syndrome (CRS) presenting as fever, whereas rare neurotoxicity is closely monitored through frequent cognitive testing and treated with steroids and late immune system effects like urinary tract infections (UTIs), respiratory infections, and shingles occur in the first 6 months post treatment but resolve with appropriate medications and prophylactic treatments, with outcomes improving significantly when CAR T is used earlier in treatment lines rather than after patients have exhausted all other options.

Panelists discuss how patients with multiple myeloma can achieve excellent quality of life with bispecific therapies like talquetamab despite manageable adverse effects, with Karen sharing her advice to embrace treatment opportunities, accept a "new normal," and focus on the meaningful life experiences these innovative therapies enable, including her recent trip to Italy and time with 6 grandchildren she wouldn't have met without these advancing treatments.

Panelists discuss how nursing support for chimeric antigen receptor (CAR) T-cell therapy success involves providing comprehensive educational materials covering everything from collection to survivorship, conducting virtual CAR T classes, and adapting to new outpatient CAR T protocols where patients receive cells and go home with vital sign monitoring equipment for caregivers. The panelists also celebrate recent FDA regulatory changes that reduced required stay times from 4 weeks to 2 weeks and driving restrictions from 8 weeks to 2 weeks, making CAR T therapy more accessible by allowing patients to return to work and normal life sooner, with reduced financial burden on families.

Dordaviprone was recommended at a dose of 625 mg orally once weekly for adults, and the recommended dosage is based on body weight for pediatric patients.

Extended follow-up for individuals with H3K27M-mutated diffuse midline glioma may help explain the duration of response across patient subgroups.

An expert discusses that combining the bispecific antibodies teclistamab and talquetamab has shown promising efficacy and manageable toxicity in heavily pretreated multiple myeloma patients—including those with extramedullary disease—offering a compelling dual-targeted option for high-risk cases while allowing flexibility in sequencing for slower-progressing disease.

Geraldine O’Sullivan Coyne, MD, PhD, MRCPI, described the excitement of seeing novel molecules such as antibody-drug conjugates become more prominent.

Ronald Bleday, MD, credits a chronic pain clinic for consulting patients who may be at a greater risk for prolonged opioid use following surgery.

Panelists discuss how voracidinib shows superior brain penetration compared to other IDH inhibitors and explore exciting combination approaches with immunotherapy and vaccines that target the immunosuppressive effects of 2-HG in the tumor microenvironment.

The primary end points of the EPCORE FL-1 trial were met while assessing an epcoritamab-based combination for patients with R/R follicular lymphoma.

Panelists discuss how to implement hepatotoxicity monitoring protocols, counsel patients about avoiding hepatotoxic substances, and manage the infrequent but manageable liver enzyme elevations that typically occur within the first 6 months of treatment.

Panelists discuss how their key takeaways emphasize the importance of communication and collaboration between academic centers and community practices to ensure equitable access to bispecific therapies, highlighting that it’s an exciting time in myeloma treatment with patient-friendly options that can be administered closer to home, and concluding that virtually no patient should be denied exposure to bispecific therapy before discontinuing treatment, while anticipating that de-escalated Q4 weekly schedules and trispecific agents will transform current practice patterns in the coming years.