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Opinion|Videos|February 10, 2025

Locally Advanced Triple-Negative Breast Cancer

Author(s)Rahul Gosain, MD, Rohit Gosain, MD, Virginia Kaklamani, MD, DSc

Panelists discuss how locally advanced triple-negative breast cancer (LATNBC) is an aggressive breast cancer subtype characterized by absence of estrogen receptor, progesterone receptor, and HER2 protein expression. It presents with large tumors and/or extensive lymph node involvement without distant metastasis. Treatment typically involves neoadjuvant chemotherapy followed by surgery and radiation.

Episodes in this series

EP. 1 Early-Stage Triple-Negative Breast Cancer

EP. 1 Early-Stage Triple-Negative Breast Cancer

EP. 2 Locally Advanced Triple-Negative Breast Cancer

EP. 2 Locally Advanced Triple-Negative Breast Cancer

EP. 3 Navigation of Triple-Negative Breast Cancer Treatment Toxicities

EP. 3 Navigation of Triple-Negative Breast Cancer Treatment Toxicities

EP. 4 Approach to Metastatic Disease

EP. 4 Approach to Metastatic Disease

EP. 5 Clinical Pros of Sacituzumab and T-DXd

EP. 5 Clinical Pros of Sacituzumab and T-DXd

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