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Opinion|Videos|September 26, 2024

MANIFEST-2: Pelabresib in Myelofibrosis: MOA, Study Design, and Spleen Volume Reduction

Author(s)David M. Swoboda, MD, Andrew T. Kuykendall, MD

Panelists discuss the MANIFEST-2 trial of pelabresib in myelofibrosis, focusing on its mechanism of action (MOA), study design, and impact on spleen volume reduction.

Episodes in this series

EP. 1 Myelofibrosis: Background, Risk Stratification, and Treatment Decision-Making

EP. 1 Myelofibrosis: Background, Risk Stratification, and Treatment Decision-Making

EP. 2 Approved and Investigational Agents for Myelofibrosis

EP. 2 Approved and Investigational Agents for Myelofibrosis

EP. 3 Disease Modification Strategies and Unmet Needs in Myelofibrosis

EP. 3 Disease Modification Strategies and Unmet Needs in Myelofibrosis

EP. 4 MANIFEST-2: Pelabresib in Myelofibrosis: MOA, Study Design, and Spleen Volume Reduction

EP. 4 MANIFEST-2: Pelabresib in Myelofibrosis: MOA, Study Design, and Spleen Volume Reduction

EP. 5 Disease- Modifying Biomarker Data in the MANIFEST-2 Study Investigating Pelabresib

EP. 5 Disease- Modifying Biomarker Data in the MANIFEST-2 Study Investigating Pelabresib

EP. 6 Safety Profile of the Pelabresib and Ruxolitinib Combination in Myelofibrosis

EP. 7 Pelabresib in MPNs: Immune Profiles of Responders vs. Non-responders

EP. 7 Pelabresib in MPNs: Immune Profiles of Responders vs. Non-responders

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