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Opinion|Videos|January 27, 2026

Prophylaxis and Practical Implementation of the COPERNICUS Approach

Author(s)Edgardo Santos, MD, FACP, FASCO

This study explores the efficacy and safety of Amivantamab plus Lazertinib for patients with EGFR mutations and brain metastasis.

Episodes in this series

1 expert is featured in this series.

EP. 1 Introducing COPERNICUS: Clinical Gaps and the Rationale for a New First-Line Strategy

1 expert is featured in this series.

EP. 2 Supportive Care Evidence Shaping COPERNICUS: Lessons From PALOMA three, COCOON, and SKIPPirr

1 expert is featured in this series.

EP. 3 Study Population and Cohort Design: Reflecting Real World EGFR Mutant NSCLC

1 expert is featured in this series.

EP. 4 End Points and Objectives: Capturing Efficacy, Safety, and Patient Experience

1 expert is featured in this series.

EP. 5 Prophylaxis and Practical Implementation of the COPERNICUS Approach

The final section integrates the full COPERNICUS strategy, focusing on proactive toxicity prevention and real world applicability. Dr Santos details the structured prophylactic regimens designed to minimize common adverse events associated with amivantamab and lazertinib. Administration reaction prophylaxis includes dexamethasone based on SKIPPirr data, while venous thromboembolism prevention is addressed through prophylactic anticoagulation.

Dermatologic prophylaxis, informed by COCOON, is presented as a cornerstone of the study. Strategies include early use of oral antibiotics, topical therapies, nail care, moisturization, and sun protection. Dr Santos emphasizes that these measures are practical and familiar to oncology teams, making them feasible to implement outside of clinical trials.

The section concludes by reinforcing the broader clinical relevance of COPERNICUS. Subcutaneous amivantamab administered every four weeks, combined with oral lazertinib and comprehensive supportive care, represents a patient centered approach that builds on established efficacy while addressing real world challenges. COPERNICUS is positioned as a meaningful step toward optimizing how effective therapies are delivered in everyday oncology practice.

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