While response rates of 50% have been reported after treatment of patients with low-grade follicular non-Hodgkin’s lymphoma (NHL) using the chimeric monoclonal anti-CD20 antibody rituximab (Rituxan), only minimal data are available on
While response rates of 50% have been reported after treatment of patients with low-grade follicular non-Hodgkin’s lymphoma (NHL) using the chimeric monoclonal anti-CD20 antibody rituximab (Rituxan), only minimal data are available on therapeutic results in patients with mantle cell lymphoma (MCL) or aggressive CD20-positive NHL. We report on 25 patients with intermediate- or high-grade NHL treated with 375 mg/m² of rituximab once weekly for 4 weeks.
Patients had either diffuse large B-cell lymphoma (DLBCL; N = 14), transformed follicular B-NHL (N = 7), or MCL (N = 4). Median age was 60 years (range, 36 to 81 years), and most patients (N = 17) had stage III/IV disease. At the time of treatment, 21 patients were in second or higher relapse, having received a median of two prior chemotherapeutic regimens. Three elderly patients (> 65 years old) were treated at first diagnosis.
Side effects were transient and of National Cancer Institute (NCI) grade 1/2 toxicity. Grade 3-4 adverse events occurred significantly less often than in patients with low-grade NHL (P < .01). So far, 23 patients are evaluable for response. There was 1 complete response (CR; duration, 3+ months) in 12 patients with primary DLBCL. Of seven patients with transformed follicular lymphoma, one achieved a CR (12+ months) and two patients had partial responses (PRs; 6 and 9 months). Two of four patients with MCL achieved a CR (8+ and 19+ months).
CONCLUSION: Although toxicity of rituximab was very low in patients with mantle cell NHL and aggressive B-NHL, efficacy was dependent on the lymphoma subtype. Remission rates up to 50% were observed in patients with transformed follicular NHL, as well as in patients with MCL. Further clinical studies are needed to investigate the activity of rituximab in aggressive lymphoma, either alone or in combination with chemotherapeutic regimens.
Click here for Dr. Bruce Cheson’s commentary on this abstract.
Between the Lines Podcast: Tazemetostat in Relapsed/Refractory Follicular Lymphoma
November 3rd 2022Expert oncologist/hematologists Bruce Cheson, MD, FACP, and Steven Park, MD, discuss findings from the E7438-G000-101 trial and consider the efficacy of tazemetostat as treatment for relapsed or refractory follicular lymphoma.