Diffuse Large B-Cell Lymphoma | Topics

Atezolizumab With R-CHOP Shows Long-Lasting Activity in Previously Untreated DLBCL
November 04, 2022

Atezolizumab plus R-CHOP appeared to yield durable clinical benefit and a safety profile consistent with known toxicities in patients with previously untreated DLBCL, according to data from a phase 1b/2 trial.

Tafasitamab Plus Lenalidomide Improve Outcomes Vs Systemic Therapies in Relapsed/Refractory DLBCL
October 09, 2022

Tafasitamab plus lenalidomide prolonged overall survival compared with systemic therapies in patients with relapsed/refractory diffuse large B-cell lymphoma, according to data from the retrospective RE-MIND2 study.

DLBCL Outcomes May be Predicted Using ctDNA as Prognostic Tool
September 12, 2022

Circulating tumor DNA levels could be a potential prognostic tool for predicting outcomes in diffuse large B-cell lymphoma.

Promising Efficacy Seen With Addition of Orelabrutinib to R-CHOP in Non-GCB DLBCL
September 12, 2022

In patients with non-germinal center B cell–like diffuse large B-cell lymphoma, the combination of orelabrutinib plus R-CHOP revealed an overall response rate of 86.4%.

Supplemental BLA Accepted by FDA for Polatuzumab Vedotin/R-CHP Combo for Previously Untreated DLBCL
August 17, 2022

Patients with previously untreated diffuse large B-cell lymphoma may benefit from treatment with polatuzumab vedotin-piiq plus rituximab, cyclophosphamide, doxorubicin, and prednisone, for which a supplemental biologics license application was accepted by the FDA.

Relapsed or Refractory Diffuse Large B-Cell Lymphoma: “Dazed and Confused”
June 16, 2022

This review article written by Meghana Kesireddy, MBBS and Matthew A. Lunning, MD, reviews management and treatment of relapsed/refractory large B-cell lymphoma.

Tafasitamab Plus Lenalidomide Superior to Standard Therapies in Key Subgroups of High-Risk R/R DLBCL
June 06, 2022

Subgroup analysis of the RE-MIND trial support use of tafasitamab plus lenalidomide to treat high-risk diffuse large B-cell lymphoma.

Early Data Show Epcoritamab Induces Responses in High-Risk DLBCL in First Line
June 04, 2022

High response rates were noted in a phase 1/2 trial of the bispecific antibody epcoritamab to treat first-line, high-risk diffuse large B-cell lymphoma.

Current Frontline Treatment of Diffuse Large B-Cell Lymphoma
January 20, 2022

This review article discusses which frontline treatment are best for diffuse large B-cell lymphoma.

FDA Grants Regenerative Medicine Advanced Therapy and Fast Track Designations to C-CAR039 for Relapsed/Refractory DLBCL
January 12, 2022

A bi-specific anti-CD19/CD20 CAR T-cell therapy, C-CAR039, received a regenerative medicine advanced therapy designation and fast track designation from the FDA for treating patients with relapsed/refractory diffuse large B cell lymphoma.