Gastrointestinal Cancer

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LISBON, Portugal--Although folinic acid and interferon have been shown to heighten the efficacy of 5-fluorouracil (5-FU) in colorectal cancer, the ability of these biochemical modulators to prolong survival is less certain. Now a prospective randomized trial conducted in Germany has revealed that patients with advanced, symptomatic colorectal cancer who are treated with 5-FU and folinic acid live longer and have a better quality of life than do those who receive 5-FU and interferon.