April 12th 2024
LYT-200 is currently being investigated for those with solid tumors and hematologic malignancies.
Equalizing Inequities™ in Multiple Myeloma Care: Shining a Light on Current Barriers and Opportunities for Improved Outcomes
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Community Oncology Connections™: Overcoming Barriers to Testing, Trial Access, and Equitable Care in Cancer
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Commentary (Schuller): Speech and Swallowing Rehabilitation for Head and Neck Cancer Patients
May 1st 1997This paper is an excellent overview of speech and swallowing rehabilitation in head and neck cancer patients. Dr. Logemann and co-workers are clearly leaders in this field and, as such, are eminently qualified to summarize the topic. This subject is of great importance, as the effects of head and neck cancer and its treatment can be economically, psychologically, and socially devastating to patients. Quality-of-life issues continue to be critical in this patient population.
Commentary (Spaulding): Speech and Swallowing Rehabilitation for Head and Neck Cancer Patients
May 1st 1997Logemann and colleagues highlight an aspect of the treatment of patients with head and neck cancer that is frequently ignored; ie, the importance of rehabilitation efforts and evaluations of post-therapy quality of life. As oncologists, whether surgical, radiation, or medical, our studies and publications have traditionally focused on overall survival, disease-free survival, and, particularly in the management of head and neck cancer, local control of disease. More recently, investigators have begun to address quality of life when constructing studies for patients with all kinds of malignancies, and newer performance outcome instruments have been designed specifically for patients with head and neck cancer.[1]
Quality of Life After Radiation Therapy for Base of Tongue Cancer
November 1st 1996The article by Moore provides an example of much needed research evaluating clinical outcomes in head and neck oncology. Measuring the quality of life (QOL) of patients with head and neck cancer presents some unique challenges. First, head and neck cancer profoundly influences some of the most fundamental functions of life, including breathing, eating, and communication. Second, treatment of head and neck cancer does not always improve these functional deficits, and in many instances, the treatment itself results in further deterioration of these functions. Finally, "traditional" outcome measures (disease-free survival, overall survival, local and regional control, response rates) do not adequately assess the global impact of this disease and/or its treatment on patients' perception of life satisfaction.
Hopkins Researchers Find Genetic Alterations Linked to Cancer in Some Blood Samples
October 1st 1996Using a new molecular test, investigators at The Johns Hopkins University School of Medicine have detected genetic mutations specific to cancer in blood samples of six patients with head and neck cancer. Their findings are reported in the September issue of Nature Medicine.
Voice-Rehabilitating Surgery at Time of Larynx Removal Benefits Head & Neck Cancer Patients
October 1st 1996At the 4th International Conference of Head and Neck Cancer held in Toronto, Canada, Robert H. Maisel, md, an otolaryngologist at the University of Minnesota Cancer Center, advocated performing tracheoesophageal puncture (TEP) at the time of surgical removal of the voice box due to cancer. While the voice-rehabilitating surgical procedure has been part of the cancer operation since 1985, it has traditionally been performed several months after removal of the larynx.
Multimodality Approaches Used in Esophageal Cancer
September 1st 1996NIJMEGEN, The Netherlands--With 12,000 new cases of esophageal cancer diagnosed every year in the United States, and 5-year postoperative survival rates still hovering under 20%, the need to develop more effective multimodality treatment strategies remains crucial, said David Ilson, MD, of Memorial Sloan-Kettering Cancer Center.
Detection of Nodal Micrometastases in Head and Neck Cancer by Serial Sectioning and Immunostaining
August 1st 1996We investigated the incidence of micrometastases from squamous cell carcinomas of the head and neck in neck dissection specimens originally staged as pN0. A total of 76 dissection specimens from 60 patients were
Docetaxel Said to Be Highly Effective and and Well Tolerated in Advanced Head and Neck cancer.
March 1st 1996Docetaxel {Taxotere) demonstrated significant activity and was well tolerated in the treatment of advanced head and neck cancer, according to preliminary results of a phase II clinical trial presented at the Eighth Annual European Congress for Clinical Oncology (ECCO-8) in Paris.
Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer?
March 1st 1996The review by Mendenhall et al presents selected papers pertinent to the effect of metastatic nodes on local control in patients with head and neck cancer. These data are retrospective and, as the authors point out, do not resolve the matter.
Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer?
March 1st 1996The article by Mendenhall et al represents a comprehensive review of their own experience, as well as other large experiences in the literature, aimed at addressing the controversy of whether neck stage predicts local control after irradiation of head and neck cancer. The authors systematically explore this controversy in the setting of both definitive and postoperative therapy. Based on this review, and our own experience, we conclude that there are no significant data showing a correlation between neck stage and local control at the primary tumor site following irradiation of head and neck carcinoma.
A Multicenter Maintenance Study of Oral Pilocarpine Tablets for Radiation-Induced Xerostomia
March 1st 1996Two hundred sixty-five patients with head and neck cancer who had previously participated in either a fixed-dose, dose-titration, or dose-ranging trial of oral pilocarpine hydrochloride tablets were enrolled in a 36-month
Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer?
March 1st 1996The impact of neck stage (N stage) on local control after treatment for head and neck cancer is controversial. This article reviews the pertinent literature. Based on this review, the authors conclude that although N stage
Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer?
March 1st 1996The paper by Mendenhall et al addresses a very debatable issue, ie, the influence of nodal stage on local control for head and neck carcinomas treated by radiotherapy. The paper is well written and appropriately referenced, and the authors fairly conclude that, based on currently available data, nodal stage has no clear impact on the probability of primary local control after radiotherapy.
Inclusion of Comorbidity in a Staging System for Head and Neck Cancer
September 1st 1995The widespread use of the TNM staging system has helped standardize the classification of cancers. Despite its excellence in describing a tumor's size and extent of anatomic spread, the TNM system does not account for the clinical biology of the cancer.
Commentary (Chen/Feigal): Inclusion of Comorbidity in a Staging System for Head and Neck Cancer
September 1st 1995The tumor, node, metastases (TNM) cancer staging system is widely accepted by physicians as a predictor of prognosis and as a guide to therapy. Multiple national and international organizations, including the American Joint Committee on Cancer and the TNM Committee of the International Union Against Cancer have periodically evaluated and revised this international staging system since it was first proposed over four decades ago [1].