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SAN FRANCISCO-Whole-field radiotherapy improves progression-free survival in prostate cancer patients who have a 15% or greater risk of lymph node involvement, compared with prostate-only radiotherapy, according to a study presented at the 43rd Annual Meeting of the American Society for Therapeutic Radiology and Oncology (plenary 5).
Fenretinide (N-4-hydroxyphenyl-retinamide, or 4-HPR) is a semisynthetic retinoid that was initially developed as a low-dose chemopreventative agent.[1-3] Unlike other naturally occurring retinoids such as all-trans, 13-cis, and 9-cis retinoic acids, fenretinide does not induce systemic catabolism that interferes with the maintenance of effective plasma levels during long-term use. This characteristic, combined with the agent’s low toxicity and its ability to block aspects of carcinogenesis, provided the rationale for the development of fenretinide in lower doses as a chemoprevention agent for breast, prostate, and bladder cancer.
ANAHEIM, California-The outcome of patients with clinically localized prostate cancer can be improved with aggressive treatment, according to two large studies presented at the American Urological Association annual meeting.
A study that evaluated 76 patients, aged 48 to 62 years, who underwent prostate brachytherapy between 1995 and 1999 using either palladium-103 or iodine-125 seed implants, reported that more than 98% achieved 5-year survival.
Clinical applications of image-based radiation therapy for the study of prostate cancer have expanded significantly over the past years. The results of recent studies of magnetic resonance imaging (MRI) combined with magnetic
Clinical applications of image-based radiation therapy for the study of prostate cancer have expanded significantly over the past years. The results of recent studies of magnetic resonance imaging (MRI) combined with magnetic
Clinical applications of image-based radiation therapy for the study of prostate cancer have expanded significantly over the past years. The results of recent studies of magnetic resonance imaging (MRI) combined with magnetic
The National Cancer Institute (NCI) and the Community Cancer Research Consortium (part of the Southwest Oncology Group [SWOG]) have launched a major study examining the roles of vitamin E and selenium in the prevention of prostate
Clinical applications of image-based radiation therapy for the study of prostate cancer have expanded significantly over the past years. The results of recent studies of magnetic resonance imaging (MRI) combined with magnetic
ANAHEIM, California-In hormone-refractory prostate cancer patients, bisphosphonates can relieve painful skeletal metastases, according to a study presented at the American Urological Association annual meeting (abstract 691).
ANAHEIM, California-Prostate cancer can now be added to the list of malignancies for which nonsteroidal anti-inflammatory agents (NSAIDs) may have a protective effect, according to experimental and clinical research presented at the American Urological Association annual meeting.
ANAHEIM, California-An investigational antisense oligonucleotide directed against bcl-2 appears to help overcome the resistance of hormone-refractory prostate cancer to docetaxel (Taxotere). The combination of bcl-2 antisense (G3139, Genasense) and docetaxel, therefore, may prove to be effective in this type of cancer, researchers from the University of Texas Health Science Center, San Antonio, said at the American Urological Society annual meeting (abstract 690).
EAST LANSING, Michigan-A study of 841 patients age 65 and older newly diagnosed with breast, colon, lung, or prostate cancer found three predictors of pain and fatigue: advanced stage, more comorbid conditions, and lung cancer, compared with breast cancer (the reference), according to researchers from Michigan State University.
SAN FRANCISCO-In men with localized or locally advanced prostate cancer, immediate treatment with the nonsteroidal antiandrogen bicalutamide (Casodex), alone or in addition to standard therapy, significantly reduces disease progression.
ANAHEIM, California-The timing of androgen deprivation therapy for prostate cancer may well affect disease-specific survival, according to two studies presented at the American Urological Association annual meeting.
SAN FRANCISCO-Patients with hormone-refractory prostate cancer benefited from a regimen combining paclitaxel (Taxol) and estramustine (Emcyt, Estracyt) in two phase II trials discussed at the 37th Annual Meeting of the American Society of Clinical Oncology (ASCO).
BETHESDA, Maryland-Researchers have begun accruing 32,400 men for a long-term prostate cancer study that will test whether selenium and/or vitamin E can prevent the disease. The Southwest Oncology Group (SWOG) will coordinate the Selenium and Vitamin E Cancer Trial (SELECT) at more than 400 sites in the United States, Canada, and Puerto Rico. Participants will be followed for up to 12 years.
The Food and Drug Administration (FDA) and the National Cancer Institute (NCI) inaugurated a new program in July that
Most men diagnosed with prostate cancer are more than 65 years of age. Therefore, a discussion of the issues surrounding the diagnosis, prevention, and treatment of prostate cancer in older men is, in many ways, a review of
BMS-247550 is a methyl, semi-synthetic analog of the natural product epothilone B. Provided to the National Cancer Institute (NCI) by Bristol-Myers Squibb, BMS-247550 was chosen for clinical development because it demonstrated
Most men diagnosed with prostate cancer are more than 65 years of age. Therefore, a discussion of the issues surrounding the diagnosis, prevention, and treatment of prostate cancer in older men is, in many ways, a review of
Most men diagnosed with prostate cancer are more than 65 years of age. Therefore, a discussion of the issues surrounding the diagnosis, prevention, and treatment of prostate cancer in older men is, in many ways, a review of
ANAHEIM, California-Abarelix, an injectable gonadotropin-releasing hormone (GnRH) antagonist, reduces serum prostate-specific antigen (PSA) levels and testosterone levels more than standard therapy, with less hormonal "surge," according to several studies presented at the American Urological Association (AUA) annual meeting.
ST. LOUIS-Three-dimensional (3D) conformal radiation therapy is being widely used for treatment of prostate cancer and has been successful at reducing rectal toxicities. "Conformal radiotherapy has allowed dose escalation with acceptable or even reduced rates of severe morbidity," Jeff M. Michalski, MD, reported. He added, however, that "we have to start paying attention to the low-grade morbidity. Grade 1 and grade 2 toxicity may predict development of severe late complications." Dr. Michalski is assistant professor of radiology, Mallinckrodt Institute of Radiology, Washington University, St. Louis.
DETROIT-Intrarectal topical application of amifostine (Ethyol), given as a "mini-enema," is extremely tolerable, produces no systemic toxicity, and may be an alternative to systemic administration for preventing rectal damage in patients undergoing radiotherapy for prostate cancer. Results of a phase I study were reported by Edgar Ben-Josef, MD. He is associate professor in the Department of Radiation Oncology at Wayne State University’s Karmanos Cancer Institute in Detroit.
