FACE-OFF: CAR T-cell Therapy for R/R DLBCL ASTCT/CIBMTR 2026
EP. 1: Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)
ByTara M. Graff, DO, MS,Elizabeth Budde, MD PhD,Alex Herrera, MD,Geoffrey Shouse, DO, PhD ,Abhinav Deol, MD,Olalekan Oluwole, MD MPH,Nirav Niranjan Shah, MD Panelists examine real-world comparative data from the French DESCAR-T registry and REALYSA cohort evaluating second-line axicabtagene ciloleucel versus standard-of-care salvage therapy in early relapsed/refractory DLBCL. The discussion highlights the event-free survival with CAR T-cell therapy (1-year EFS 46% vs 16% in SOC). Faculty also discuss the impact of third-line CAR T use in the SOC arm and what these real-world registry data mean for routine second-line treatment decision-making.
EP. 2: Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)
ByTara M. Graff, DO, MS,Elizabeth Budde, MD PhD,Alex Herrera, MD,Geoffrey Shouse, DO, PhD ,Abhinav Deol, MD,Olalekan Oluwole, MD MPH,Nirav Niranjan Shah, MD Panelists analyze comparative real-world data from the French DESCAR-T registry evaluating axicabtagene ciloleucel and lisocabtagene maraleucel in second-line relapsed/refractory LBCL. Faculty consider distinctions in toxicity profiles along with selection bias, vein-to-vein time, patient frailty, and whether certain patients may preferentially benefit from one CAR T product over another in routine second-line practice.
