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Opinion|Videos|March 6, 2026

Debate Round 2: CAR T Decision in Rapidly Progressing LBCL

Author(s)Tara M. Graff, DO, MS, Elizabeth Budde, MD PhD, Alex Herrera, MD

Panelists debate how to select between axicabtagene ciloleucel and lisocabtagene maraleucel for patients with rapidly progressive second-line DLBCL. Key arguments examine differences in efficacy signals, vein-to-vein time, and toxicity profiles and how these factors influence urgency of treatment. Faculty explore how real-world experience, institutional infrastructure, and patient-specific risk factors and lifestyle shape optimal CAR T product selection.

Episodes in this series

7 experts are featured in this series.

EP. 1 Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)

7 experts are featured in this series.

EP. 2 Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)

7 experts are featured in this series.

EP. 3 US Real World CAR-T Patterns in R/R LBCL (ASH 2025 Updates from ABC Consortium)

7 experts are featured in this series.

EP. 4 Debate Round 1: Treatment selection in biologically aggressive DLBCL

7 experts are featured in this series.

EP. 5 Debate Round 2: CAR T Decision in Rapidly Progressing LBCL

7 experts are featured in this series.

EP. 6 Debate Round 3: CAR-T vs Bispecifics in R/R LBCL

Panelists debate how to select between axicabtageneciloleucel and lisocabtagenemaraleucel for patients with rapidly progressive second-line DLBCL. Key arguments examine differences in efficacy signals, vein-to-vein time, and toxicity profiles and how these factors influence urgency of treatment. Faculty explore how real-world experience, institutional infrastructure, and patient-specific risk factors and lifestyle shape optimal CAR T product selection.

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7 experts are featured in this series.

Debate Round 3: CAR-T vs Bispecifics in R/R LBCL

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Sequencing Strategies and Safety Priorities for High Risk, Bispecific Exposed Patients Preparing for CAR T-Cell Therapy

ByKrina Patel, MD, MSc ,Noopur Raje, MD,Gurbakhash Kaur, MD

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