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Opinion|Videos|March 13, 2026

CAR-T Decision Making in A Case of Primary Refractory DLBCL

Author(s)Tara M. Graff, DO, MS, Elizabeth Budde, MD PhD, Alex Herrera, MD

Faculty analyze a primary refractory, high-intermediate–risk DLBCL case with persistent PET-positive disease after frontline R-CHOP and symptomatic progression. Discussion focuses referral for second-line CAR T and how rural geography and distance from a CAR-T center influence logistics. Panelists weigh aggressive disease biology against access barriers and caregiver availability in determining next steps.

Episodes in this series

7 experts are featured in this series.

EP. 1 Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)

7 experts are featured in this series.

EP. 2 Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)

7 experts are featured in this series.

EP. 3 US Real World CAR-T Patterns in R/R LBCL (ASH 2025 Updates from ABC Consortium)

7 experts are featured in this series.

EP. 4 Debate Round 1: Treatment selection in biologically aggressive DLBCL

7 experts are featured in this series.

EP. 5 Debate Round 2: CAR T Decision in Rapidly Progressing LBCL

7 experts are featured in this series.

EP. 6 Debate Round 3: CAR-T vs Bispecifics in R/R LBCL

7 experts are featured in this series.

EP. 7 CAR-T Decision Making in A Case of Primary Refractory DLBCL

7 experts are featured in this series.

EP. 8 Relapsed DLBCL: Navigating CAR-T Logistics, Work, and Caregiving

Faculty analyze a primary refractory, high-intermediate–risk DLBCL case with persistent PET-positive disease after frontline R-CHOP and symptomatic progression. Discussion focuses referral for second-line CAR T and how rural geography and distance from a CAR-T center influence logistics. Panelists weigh aggressive disease biology against access barriers and caregiver availability in determining next steps.

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