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Opinion|Videos|February 20, 2026

Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)

Author(s)Tara M. Graff, DO, MS, Elizabeth Budde, MD PhD, Alex Herrera, MD

Panelists examine real-world comparative data from the French DESCAR-T registry and REALYSA cohort evaluating second-line axicabtagene ciloleucel versus standard-of-care salvage therapy in early relapsed/refractory DLBCL. The discussion highlights the event-free survival with CAR T-cell therapy (1-year EFS 46% vs 16% in SOC). Faculty also discuss the impact of third-line CAR T use in the SOC arm and what these real-world registry data mean for routine second-line treatment decision-making.

Episodes in this series

7 experts are featured in this series.

EP. 1 Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)

7 experts are featured in this series.

EP. 2 Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)

Panelists discuss how to optimally integrate CAR T-cell therapy into second-line treatment for diffuse large B-cell lymphoma through a competitive, team-based format. The debates highlight real-world updates presented at the American Society of Hematology Annual Meeting 2025, explores evolving sequencing strategies versus salvage chemotherapy and transplant, and examines patient selection, referral timing, and outpatient delivery considerations. The program concludes with case-based analysis to translate emerging evidence into practical decision-making for community oncology practice.

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Related Content

7 experts are featured in this series.

Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)

ByTara M. Graff, DO, MS,Elizabeth Budde, MD PhD,Alex Herrera, MD,Geoffrey Shouse, DO, PhD ,Abhinav Deol, MD,Olalekan Oluwole, MD MPH,Nirav Niranjan Shah, MD

February 20th 2026

3 experts are featured in this series

Streamlining CAR T-Cell Care Coordination and Evolving Outpatient Management in Multiple Myeloma

ByKrina Patel, MD, MSc ,Noopur Raje, MD,Gurbakhash Kaur, MD

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Experts featured in this series.

ALPINE Lont-Term Follow-Up: Zanubrutinib, Venetoclax Combinations, and Long-Term Outcomes

ByIan Flinn, MD, PhD,Danielle Brander, MD

February 20th 2026

3 experts are featured in this series

Communicating the CAR T-Cell Treatment Experience to Support Patient Decision Making in Multiple Myeloma

ByKrina Patel, MD, MSc ,Noopur Raje, MD,Gurbakhash Kaur, MD

February 20th 2026

Experts featured in this series.

Practical Considerations for Integrating Zanubrutinib Plus Venetoclax in CLL Therapy

ByIan Flinn, MD, PhD,Danielle Brander, MD

February 20th 2026

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