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Opinion|Videos|March 6, 2026

Debate Round 3: CAR-T vs Bispecifics in R/R LBCL

Author(s)Tara M. Graff, DO, MS, Elizabeth Budde, MD PhD, Alex Herrera, MD

Panelists debate whether the treatment paradigm in relapsed/refractory LBCL has fundamentally shifted from salvage chemotherapy and autologous transplant toward novel immune-based strategies. The discussion centers on CAR T-cell therapy versus bispecific antibodies, examining differences in outcomes. Faculty explore how emerging data, sequencing considerations, and real-world constraints are redefining treatment decision-making.

Episodes in this series

7 experts are featured in this series.

EP. 1 Key Perspectives on Real World CAR-T Use in R/R LBCL (DESCAR-T & REALYSA Registries)

7 experts are featured in this series.

EP. 2 Examining CAR-T Outcomes in 2L LBCL Treatment (Axi-cel & Liso-cel, DESCAR-T Registry)

7 experts are featured in this series.

EP. 3 US Real World CAR-T Patterns in R/R LBCL (ASH 2025 Updates from ABC Consortium)

7 experts are featured in this series.

EP. 4 Debate Round 1: Treatment selection in biologically aggressive DLBCL

7 experts are featured in this series.

EP. 5 Debate Round 2: CAR T Decision in Rapidly Progressing LBCL

7 experts are featured in this series.

EP. 6 Debate Round 3: CAR-T vs Bispecifics in R/R LBCL

Panelists debate whether the treatment paradigm in relapsed/refractory LBCL has fundamentally shifted from salvage chemotherapy and autologous transplant toward novel immune-based strategies. The discussion centers on CAR T-cell therapy versus bispecific antibodies, examining differences in outcomes. Faculty explore how emerging data, sequencing considerations, and real-world constraints are redefining treatment decision-making.

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