ONCOLOGY Vol 13 No 5 | Oncology

Thalidomide Shows Promising Results in Patients With Multiple Myeloma

May 01, 1999

Research investigating the use of thalidomide in multiple myeloma report that 34% of patients treated with the drug experienced a reduction in tumor burden. Some patients experienced more than a 7,500-fold reduction in tumor growth,

Reinventing Bone Marrow Transplantation

May 01, 1999

The article by Champlin and colleagues summarizes exciting recent clinical results in allogeneic bone marrow transplantation (BMT) for leukemia and lymphoma achieved by “reengineering” the process to take maximum advantage of the powerful

Age Should Not Determine Treatment of SCLC Patients

May 01, 1999

A study published in a recent issue of the International Journal of Radiation Oncology, Biology, and Physics found that elderly patients with limited small-cell lung cancer (SCLC) can tolerate radiation and should not be denied potentially curative

Single Chest X-Ray Leads to Improved Lung Cancer Prognosis

May 01, 1999

Finnish investigators recently reported that the survival rates of patients whose lung cancer was found during screening with a single chest radiograph were significantly higher than survival rates in patients whose cancer was detected through “the

A 38-Year-Old Man With Pancreatic Cancer

May 01, 1999

Michael H. Levy, MD: This 38-year-old white male first came to his physician in January of 1993 complaining of epigastric and low back pain. In March of 1993, he was diagnosed with pancreatic cancer that was metastatic to his

Thymus May Hold Clue To Rebuilding Immune System After HIV

May 01, 1999

Discovery of a marker that allows tracking of thymus function also shows how the adult immune system might repair itself after being damaged by the human immunodeficiency virus (HIV), UT Southwestern Medical Center at Dallas scientists report

Reinventing Bone Marrow Transplantation

May 01, 1999

Champlin et al review a most interesting topic that has emerged recently; namely, the use of nonmyeloablative conditioning regimens to induce immune-mediated graft-vs-leukemia (GVL) effects, or, in a more general sense, graft-vs-tumor (GVT)

Update on the Management of Advanced Breast Cancer

May 01, 1999

Fornier et al present an excellent summary of current treatment options and strategies for patients with metastatic breast cancer. This review summarizes currently available data (through the May 1998 American Society of Clinical Oncology

Reinventing Bone Marrow Transplantation

May 01, 1999

In his 1975 New England Journal of Medicine review article on bone marrow transplantation, Nobel laureate E. Donnall Thomas listed the major obstacles to successful transplantation as donor availability, graft-vs-host disease (GVHD), treatment-

Update on the Management of Advanced Breast Cancer

May 01, 1999

Drs. Fornier, Munster, and Seidman provide a comprehensive update of the management of metastatic breast cancer. They review the latest innovations in both chemotherapy and hormonal therapy for advanced disease, and demonstrate just how

Commentary (Lanzieri): Current Imaging Techniques for Head and Neck Tumors

May 01, 1999

Head and neck imaging, in its current form, really began with the development of the computed tomographic (CT) scanner in the late 1970s and early ’80s. Originally, only CT scans of the brain were performed because of constraints on gantry size.

Commentary (Keller): Surgical Staging of Lung Cancer

May 01, 1999

As Matin and Goldberg note, the accurate staging of non-small-cell lung cancer (NSCLC) is necessary to provide patients with correct information regarding prognosis and appropriate treatment recommendations. Therefore, physicians who treat

Commentary (Ginsberg): Surgical Staging of Lung Cancer

May 01, 1999

Drs. Matin and Goldberg describe and comment on the invasive techniques currently used for the clinical staging of lung cancer. Although they term this “surgical” staging, in reality, it is part of clinical staging (cTNM) and should be distinguished

Current Imaging Techniques for Head and Neck Tumors

May 01, 1999

Modern head and neck imaging has led to advances in both the diagnosis and treatment of head and neck cancers. Both computed tomography (CT) and magnetic resonance imaging (MRI) studies provide important information

Neuraxial Infusion in the Management of Cancer Pain

May 01, 1999

Pain due to malignancy can be controlled through simple means in most patients. In certain refractory cases, however, the chronic delivery of analgesics to the epidural or subarachnoid space may be appropriate. This review

Surgical Staging of Lung Cancer

May 01, 1999

The staging of lung cancer defines the extent of disease. Accurate staging is important to define operability, select treatment regimens, and predict survival. Nonsurgical and surgical techniques are used to stage patients. The

Patient and Family Caregiver Perspectives

May 01, 1999

The introduction of any new analgesic agent or delivery system is often focused on efficacy of the agent or on considerations of use by health care professionals. Introduction of novel pain technologies should also consider the

Reinventing Bone Marrow Transplantation

May 01, 1999

The therapeutic benefit of allogeneic hematopoietic transplantation is due largely to an immune graft-vs-malignancy effect. Most of the evidence for such an effect has come from studies of allogeneic transplantation in

Cost Modeling for Alternate Routes of Administration of Opioids for Cancer Pain

May 01, 1999

The economic considerations relative to neuraxial infusion can be looked at with different types of economic models, including cost-minimization, cost-effectiveness, and cost-benefit analyses. A theoretical predictive model

Practical Issues When Using Neuraxial Infusion

May 01, 1999

The pharmacologic tailoring guidelines of the World Health Organization represent the accepted treatment algorithm for the management of cancer-related pain syndromes. Unfortunately, the guidelines are only effective

Managing Cancer Pain Poorly Responsive to Systemic Opioid Therapy

May 01, 1999

Large surveys of populations with cancer pain indicate that as many as 90% of patients can attain adequate relief of pain using optimal, systemic, opioid-based pharmacotherapy. Skilled clinicians should be able to achieve

Complications of Neuraxial Infusion in Cancer Patients

May 01, 1999

Intraspinal drug delivery systems can be effective in controlling intractable pain. However, before these invasive pain therapies are initiated and to avoid or minimize any complications associated with their use, there

Update on the Management of Advanced Breast Cancer

May 01, 1999

Recent trials comparing single-agent vs combination therapy in metastatic breast cancer suggest that it may be time to reconsider the belief that combination chemotherapy is the gold standard of treatment. Based on the

ARF Tumor-Suppressor Gene: A Natural Defense Against Cancer

May 01, 1999

Scientists at Cold Spring Harbor Laboratory and St.Jude Children’s Research Hospital in Memphis, Tennessee, provide new information about one of the key “gatekeepers” of cellular health: the p19ARF (ARF) tumor-suppressor gene in an article