High Intensity Interval Training Helped Men With Localized Prostate Cancer Achieve Increased Cardiorespiratory Fitness
High intensity interval training yielded decreased prostate-specific antigen levels and velocity, as well as lowering prostate cell growth in men with localized prostate cancer.
Preoperative Chemoradiotherapy Plus Avelumab Elicits Promising Activity for Locally Advanced Rectal Cancer
The combination of standard chemoradiotherapy plus avelumab demonstrated clinical activity while maintaining a tolerable safety profile for patients with locally advanced rectal cancer.
Notable Declines Observed in Diagnosis of Common Solid Malignancies During the First Year of the COVID-19 Pandemic
New diagnoses of common cancer types declined significantly during the first year of the COVID-19 pandemic.
Gemcitabine Plus Cisplatin Provides Survival Benefit Over Fluorouracil Plus Cisplatin in Advanced Nasopharyngeal Carcinoma
Patients with advanced nasopharyngeal carcinoma and who were treated with gemcitabine plus cisplatin experienced a longer overall survival and improved progression-free survival vs fluorouracil plus cisplatin.
Latina Breast Cancer Survivors Are Less Likely to Seek Psychosocial Services Than Non-Latina Women
Latina breast cancer survivors are less likely to seek counseling due to concerns that the counselor will not understand their values or have linguistic challenges.
FDA Converts Indication for Pembrolizumab as Frontline Therapy for Bladder Cancer to Full Approval
The FDA has granted a full approval to pembrolizumab for the treatment of platinum-ineligible patients with urothelial cancer.
Post-Transplant Cyclophosphamide Appears to be a Promising Prophylactic Treatment Against GvHD in Acute Lymphoblastic Leukemia
Compared with anti-thymocyte globulin, post-transplant cyclophosphamide appears to more successfully prevent graft-versus-host disease in patients with acute lymphoblastic leukemia, resulting in a lower incidence of relapse and improved survival.
Real-World Studies Show Insufficiency For Informing Clinical, Reimbursement Decisions of Novel Cancer Drugs
Low study quality was determined in an analysis of real-world studies across multiple drug indications in cancer.
Primary Survivorship Care In Patients With Breast Cancer and Other Malignancies May Be Feasible Versus Secondary Care
Survivorship incorporated into primary cancer care may be more cost effective and lead to better clinical and patient-reported outcomes in patients with breast cancer and other malignancies.
ASTRO Publishes Clinical Guidelines for Radiotherapy in Soft Tissue Sarcoma
A new set of guidelines for utilizing radiation therapy in adult patients with soft tissue sarcoma has been published by the American Society for Radiation Oncology.
John Pagel, MD, PhD, on Promising Responses Seen With Zanubrutinib Plus Zandelisib for B-Cell Malignancies
Patients with relapsed or regractory B-cell malignancies who were treated with zanubrutinib and zandelisib demonstrated high response rates across several treatment cohorts.
Extended Interval Dosing With Zoledronic Acid in Metastatic SCLC and NSCLC Appears to Be a Safe and Reasonable Option
Patients with non–small cell lung cancer and small-cell lung cancer with bone metastases may benefit from extended dosing with zoledronic acid.
Minority Populations With Aggressive B-Cell Lymphoma Achieved Equitable Estimated Survival Through Equal Access to Care and Nurse Navigation
Minority patients with aggressive B-cell lymphoma experienced equitable outcomes through more accessible care and the use of the nurse navigators.
NCCN Issues Updated Guidelines Regarding Third COVID-19 Vaccine Booster for Those With Cancer
Updates to the National Comprehensive Cancer Network guidelines on the COVID-19 vaccine for patients with cancer indicate that this group should be prioritized for a third dose.
Extending the Use of Adjuvant Zoledronate Past 2 Years Does Not Improve Prognosis in High-Risk Early Breast Cancer
Patients with high-risk early breast cancer who received zoledronate for over 2 years did not experience an improvement in prognosis.
Oncology Peer Review On-The-Go: Two Experts Review Important R/R DLBCL Treatment Decisions and Data
Gilles Salles, MD, PhD, and Kami Maddocks, MD, discuss relapsed/refractory diffuse large B-cell lymphoma therapeutic options and important data from the L-MIND trial.
Hypofractionated Image-Guided Versus Conventionally Fractionated Radiotherapy Shows No Treatment Advantage in NSCLC With Poor Performance Status
The use of hypofractionated image-guide radiotherapy was not found to improve overall survival for patients with non–small cell lung cancer and poor performance status versus conventional fractionated radiation techniques.
OncView™ Podcast: Updates in Therapies for Relapsed/Refractory Follicular Lymphoma
This special episode of “Oncology Peer Review On-The-Go” includes a discussion on relapsed/refractory follicular lymphoma with Javier Munoz, MD, MS, FACP.
Survey Reveals Disparities in Practice Patterns and Communication About Brain Metastases
Responses to a cross-sectional survey brought to light disparities through important aspects of diagnosing and treating brain metastases.
Medical World News® Inside the Practice: CancerNetwork® With Quita Highsmith and Monica Baskin, MD, on Diversifying Clinical Trial Participation
CancerNetwork® spoke with Quita Highsmith and Monica Baskin, MD, about the Advancing Inclusive Research Alliance and efforts to include more diverse populations in clinical trials.
Atezolizumab TNBC Indication Withdrawn By Manufacturer After Talks With FDA
Atezolizumab will no longer be available for the treatment of patients with PD-L1–positive triple-negative breast cancer following withdrawal of the indication by the agent’s developer.
Prostate Cancer Treatment Was Not Associated With Cognitive Decline in Older Men
Geriatric patients with prostate cancer did not experience a decline in cognative function regardless of treatment.
Cetuximab/Avelumab Combo Yields Promising Results in Cohort of Patients With RAS Wild-Type mCRC
The phase 2 CAVE trial indicated that a combination of cetuximab and avelumab is a promising rechallenge treatment for patients with RAS wild-type metastatic colorectal cancer.
Risk of Breakthrough COVID-19 Infection May Be High in Population With Hematologic Malignancies
Patients with hematologic malignancies may be at a higher risk for breakthrough infections following full COVID-19 vaccination.
Sandra Cuellar, PharmD, BCOP, FASHP, on Cardiotoxicity With Margetuximab for HER2+ Metastatic Breast Cancer
An oncology pharmacist speaks about the occurance of left ventricular dysfunction noted with margetuximab in the treatment of HER2-positive metastatic breast cancer.
Promising Responses, Improved Skin-Related QoL Observed With Low-Dose Skin Electron Beam Therapy for Mycosis Fungoides
Low-dose rotational total skin electron beam therapy helped to improve skin-related quality of life and yielded promising responses among patients with mycosis fungoides.
Sandra Cuellar, PharmD, BCOP, FASHP, on Infusion-Related Reactions With Margetuximab for HER2+ Metastatic Breast Cancer
An oncology pharmacist talks infusion-related reactions with margetuximab in the treatment of HER2-positive metastatic breast cancer.
FDA Approves Oncomine Dx Target Test as a Companion Diagnostic for Ivosidenib in IDH1+ Cholangiocarcinoma
Oncomine Dx Target Test is now approved by the FDA as a companion diagnostic for patients with IDH1-mutant cholangiocarcinoma who may be candidates for treatment with ivosidenib.
Targeted Intraoperative Molecular Imaging Detects Nonpalpable Lung Lesions During Surgery
A novel imaging technique using the folate analog tracer FA-S0456 was able to detect small, nonpalpable lung lesions otherwise undetectable by traditional means during resection surgery.
Reduced-Intensity Allogeneic HSCT Improves Event-Free Survival in Older Patients With Myelodysplastic Syndromes
Patients with myelodysplastic syndromes showed favorable event-free survival with allogeneic stem cell transplant compared with those being treated with continuous 5-azacytidine.
