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Immune checkpoint inhibitors have demonstrated impressive activity in patients with CRC and other solid tumors that are dMMR. Researchers explore the data. 

This year has seen many advances in immunotherapy. Here is a look at some of the most significant research. 

Metastasis-directed therapy with stereotactic ablative radiotherapy has emerged as a promising complementary technique for the management of low-volume metastatic prostate cancer.

Personality disorders become exacerbated under stressful cancer-related situations and may lead to adverse consequences and outcomes.

Conversion of tryptophan to kynurenine was associated with lower survival rates.

Immunotherapy responses may not be equal between the sexes.

The approval comes one day after the FDA approved niraparib for the same subset of ovarian cancer.

Alcohol has been labeled a carcinogen by a growing number of agencies across the globe, after years of scientific and policy debate. But just how much of the cancer burden is it responsible for?

Niraparib was approved by the (FDA) for previously treated advanced ovarian, fallopian, or primary peritoneal cancers.

For the first time, researchers have isolated a subtype of gamma-delta T-cells that offers protection in women with triple-negative breast cancer.

Researchers recently looked at differences in survival time between patients with grade II and grade III spinal meningioma.

A new combination may help with overall and progression-free survival in liver cancer.

Why are geriatric patients less likely to get treated for their non-melanoma skin cancers? Researchers investigate and report. 

The agency is set to make a decision on the investigational antibody drug conjugate by the first quarter of 2020.

Researchers explore the predictive capability of EVI1 expression.

Researchers report on the BRIGHT AML 1019 Phase III trial.

A study showed patients seem to lack an understanding of the meaning of progression-free survival.

A pooled analysis of safety, efficacy of pembrolizumab in patients 75+ years of age with PD-L1+ NSCLC

The neoantigens found in the patients’ tumors (non-small-cell lung cancer) which were highly dissimilar were enriched for hydrophobic sequences, and correlated with survival rates after the PD-1 checkpoint therapy.

Researchers examine patterns of recurrence after resection of pancreatic ductal adenocarcinoma.  

Following administration of checkpoint inhibitor therapy, 2.6% of patients experienced an acute vascular event within 6 months of starting treatment.

A study found an association between treatment with ibrutinib and an increased risk for death from toxicities.

Three scientists were awarded the Nobel Prize in Physiology of Medicine for their discovery of the mechanism of how cells regulate oxygen.

A multi-institutional pilot feasibility study looks at pencil beam scanning proton beam chemoradiation therapy with 5-fluorouracil and mitomycin-C for definitive treatment of carcinoma of the anal canal.   

A survey of physicians found recruiting for trials through social media can be useful, but not for cancer therapeutic trials.

Researchers look at how mutation status can influence responses to targeted therapy in thyroid cancer. 

Researchers report on the best pembrolizumab protocol for advanced melanoma. 

Investigators report on long-term results of sentinel node (SN) approach in patients with clinical stage I testicular tumors.

Half of the cancer drug trials that led to approvals by the European Medicines Agency may have been associated with a high risk for bias.

The agency granted breakthrough therapy designation to niraparib for the treatment of men with BRCA1/2-mutant positive metastatic castration-resistant prostate cancer.