
Opinion|Videos|December 3, 2024
Bispecifics in R/R MM: AE Management and Sequencing
Author(s)Joseph R. Mikhael, MD
Panelist discusses how every drug oncologists use comes with adverse events (AEs), and with bispecifics they are seeing a similar AE profile to that seen in CAR T-cell therapy. There are 3 major AEs: cytokine release syndrome, neurological toxicity, and infections. To manage AEs, oncologists are now monitoring patients more intensely as well as engaging with the patient’s family to provide updates on the status of the patient.
Advertisement
Episodes in this series

Video content above is prompted by the following
- What AEs are you seeing in practice with bispecifics?
- What are some strategies used to manage them?
- What is your current approach to sequencing bispecifics (BCMA vs non-BCMA bispecific, CAR T vs bispecifics)?
- What insights can you share for fellow oncologists regarding sequencing?
Advertisement
Related to this article

Dirk Schadendorf, MD, discussed final STARBOARD data with encorafenib, binimetinib, and pembrolizumab and its role in BRAF V600–mutant melanoma care.

Heath Skinner, MD, PhD, discussed the 3 considerations that determine which new radiation oncology service lines his network chooses to build.

Dwight H. Owen, MBBCh, MS, discussed why severe immune-related toxicities remain hard to predict as immunotherapy combinations expand in lung cancer.

Mingjia Li, MD, discussed the limitations of current biomarkers in selecting patients with resectable NSCLC for neoadjuvant chemoimmunotherapy.

Heath Skinner, MD, PhD, discussed which new radiation oncology service lines community practices can implement, how leadership decides, and what launches require.

Jan Kitajewski, PhD, discusses how an ancestry-linked blood type may influence triple-negative breast cancer outcomes and clinical trial eligibility.

Black women die from breast cancer at rates 40% higher than white women — and are still missing from the trials that could help. Dr. Coral Omene on why.
Advertisement
Advertisement
Trending on CancerNetwork
1
Predicting Severe Immune-Related Toxicities in Lung Cancer Immunotherapy
2
Outpatient Treatment-Related Toxicity After Hospital Discharge Among Patients Receiving Lifileucel for Advanced Melanoma
3
Recapping GI Cancer at ESMO 2026: Standout Data From Phase 1 to Phase 3
4
EU Approves T-DXd for HER2+ Early Breast Cancer With Residual Disease
5



