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Opinion|Videos|December 21, 2023

Hepatotoxicity with KRASG12C Inhibitors in NSCLC

Author(s)Narjust Florez, MD

Dr Narjust Florez discusses the hepatoxicity associated with KRAS G12C inhibitors, noting both adagrasib and sotorasib pose liver damage risks, but real-world data suggests adagrasib may have a lower risk; she emphases the importance of considering other causes of hepatoxicity before attributing it solely to these therapies.

Episodes in this series

EP. 1 Current Treatment Landscape for KRASG12C-Mutated NSCLC

EP. 1 Current Treatment Landscape for KRASG12C-Mutated NSCLC

EP. 2 Treatment Options for KRASG12C Mutated NSCLC

EP. 2 Treatment Options for KRASG12C Mutated NSCLC

EP. 3 KRYSTAL-1: Follow-Up Data on Adagrasib Monotherapy in Patients with Advanced/Metastatic KRASG12C Mutated NSCLC

EP. 3 KRYSTAL-1: Follow-Up Data on Adagrasib Monotherapy in Patients with Advanced/Metastatic KRASG12C Mutated NSCLC

EP. 4 KRYSTAL-7: Efficacy and Safety of Adagrasib with Pembrolizumab in Patients With Advanced KRASG12C Mutated NSCLC

EP. 4 KRYSTAL-7: Efficacy and Safety of Adagrasib with Pembrolizumab in Patients With Advanced KRASG12C Mutated NSCLC

EP. 5 Long-Term Outcomes of Sotorasib Efficacy in Patients With KRASG12C Mutated NSCLC

EP. 5 Long-Term Outcomes of Sotorasib Efficacy in Patients With KRASG12C Mutated NSCLC

EP. 6 Hepatotoxicity with KRASG12C Inhibitors in NSCLC

EP. 6 Hepatotoxicity with KRASG12C Inhibitors in NSCLC

EP. 7 Sotorasib Versus Docetaxel for Previously Treated Patients With KRASG12C Mutated NSCLC: Data From CodeBreaK 200

EP. 7 Sotorasib Versus Docetaxel for Previously Treated Patients With KRASG12C Mutated NSCLC: Data From CodeBreaK 200

EP. 8 Managing CNS Metastases in KRASG12C Mutated NSCLC

EP. 8 Managing CNS Metastases in KRASG12C Mutated NSCLC

EP. 9 Future Directions in KRASG12C Mutated NSCLC

EP. 9 Future Directions in KRASG12C Mutated NSCLC

EP. 10 Experts Examine the Need for Targeted Therapy Options for KRAS G12C–Mutated NSCLC

EP. 10 Experts Examine the Need for Targeted Therapy Options for KRAS G12C–Mutated NSCLC

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Tiffany A. Traina, MD, FASCO; Nour Abuhadra, MD; Joshua Z. Drago, MD, MS; Ruth O’Regan, MD; Vered Stearns, MD, FASCO; Neil Vasan, MD, PhD; Anna Weiss, MD

Personalized Approaches in NSCLC: Early Detection, Molecular Testing, and Targeted Therapies

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21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

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