July 31st 2025
Oncologists explore the considerations of mirvetuximab soravtansine treatment in platinum-resistant ovarian cancer, highlighting its efficacy and the management of ocular AEs.
National Study to Follow Patient Outcomes After BRCA1 Genetic Testing
October 1st 1996SALT LAKE CITY--Myriad Genetic Laboratories, Inc. and the American College of Surgeons (ACS) have announced a long-term study that will follow the outcomes of patients currently undergoing BRCA1 genetic analysis for breast and ovarian cancer susceptibility.
Strategies for Identification and Clinical Evaluation of Promising Chemopreventive Agents
Strategies for chemopreventative drug development are based on the use of well-characterized agents, intermediate biomarkers correlating to cancer incidence, and suitable cohorts for efficacy studies. Since
NCCR Urges Congress to Support Senate Bill for Cancer Research
August 1st 1996WASHINGTON--The National Coalition for Cancer Research (NCCR) has activated its 18 member organizations to write to Congress in support of S.1897, the NIH Revitalization Act of 1996. This legislation was introduced in the US Senate by Sen. Nancy Kassebaum (R-KS) to revise and extend certain programs of the NIH, including the National Cancer Institute (NCI).
Algorithm Identifies Women at Risk of Ovarian Cancer
August 1st 1996PHILADELPHIA--New computer software is using an investigational algorithm to translate serial CA 125 values and other risk factors into a single number showing a postmenopausal women's risk of developing ovarian cancer, Steven J. Skates, PhD, assistant professor of medicine and biostatistics, Harvard Medical School, said at his American Society of Clinical Oncology poster presentation.
Onyx and Eli Lilly Expand Their Research Alliance on BRCA1
August 1st 1996RICHMOND, Ca--Onyx Pharmaceuticals has announced an extension and expansion of its research alliance with Eli Lilly focusing on BRCA1, the gene linked to increased risk of breast and ovarian cancer. Lilly has exclusive rights to the BRCA1 gene by license from Myriad Genetics, Inc.
Princess Diana Helps Raise Over $1 Million for Cancer Research
July 1st 1996CHICAGO--A visit by Her Royal Highness The Princess of Wales to the Lurie Cancer Center of Northwestern University raised more than $1 million to support cancer research and benefit patients (see photo ). The funds will go to the Lurie Cancer Center; Gilda's Club, a support group for cancer patients named for comedian Gilda Radner who died of ovarian cancer in 1989; and The Royal Marsden Hospital, London, of which The Princess is president.
Hycamtin Approved For Ovarian Cancer
July 1st 1996PHILADELPHIA--SmithKline Beecham's Hycamtin (topotecan) has received marketing clearance from the FDA for the treatment of patients with metastatic ovarian cancer after failure of initial or subsequent chemotherapy. It is the first topoisomerase I inhibitor approved for use in the United States.
Converting Quality of Life Data to 'Q' Scores Allows Comparisons
June 1st 1996FORT LAUDERDALE, Fla--Although many quality of life measures for cancer have been validated, eg, the FLIC (Functional Living Index-Cancer) and the FACT (Functional Assessment of Cancer Therapy), use of a single instrument facilitates analysis of data obtained at different sites, David F. Cella, PhD, said at the first annual conference of the National Comprehensive Cancer Network (NCCN).
Shorter Paclitaxel Infusions Add to Neuropathy Risk
June 1st 1996NEW ORLEANS--In combination with cisplatin (Platinol) for treatment of gynecologic malignancies, 3-hour infu-sional paclitaxel (Taxol) might be easier to administer but it produces more peripheral neuropathy than the standard 24-hour infusion, a Cleveland Clinic study shows.
Topotecan: Significant Activity in Ovarian Cancer
June 1st 1996ASCO--Topotecan (Hycamtin), an inhibitor of topoisomerase I, significantly increased time to disease progression--23 weeks vs 14 weeks for paclitaxel (Taxol)--when used as second-line therapy in women with recurrent ovarian cancer, James Carmichael, MD, of the University of Nottingham, said at an ASCO scientific session.
BRCA2 Gene Mutations Linked to Ovarian Cancer Cases
June 1st 1996WASHINGTON--University of Pennsylvania researchers have obtained the first "conclusive" evidence linking mutations in the recently cloned BRCA2 breast cancer gene to ovarian cancer, a discovery they say indicates that inheritance plays a significantly greater role in the disease than previously thought.
Synthetic Retinoid May Protect Against Breast Cancer Recurrence in Younger Women
June 1st 1996WASHINGTON--Interim results from an on-going Italian chemopreven-tion trial of a synthetic retinoid show a "borderline significant" protective effect against contralateral breast cancer and, to a lesser degree, against ovarian cancer, but only in premenopausal women.
Status of Radiolabeled Monoclonal Antibodies for Diagnosis and Therapy of Cancer
June 1st 1996Almost exactly one decade ago, in an editorial published in the New England Journal of Medicine [1], I noted that "progress is slow but sure" in the development of monoclonal antibodies for clinical use. At that time, only muromonab-CD3 (Orthoclone OKT3) was approved for human use to prevent rejection of kidney transplants. In the ensuing 10 years, only one oncologic monoclonal antibody product, satumomoab pendetide (OncoScint CR/OV, Cytogen, Princeton, New Jersey) [2] has been approved by the FDA. Progress surely has been slow.
Status of Radiolabeled Monoclonal Antibodies for Diagnosis and Therapy of Cancer
June 1st 1996Monoclonal antibodies (MoAbs) of murine origin, when labeled with radionuclides that emit gamma rays, target tumors, permitting detection of disease. SatumoMoAb pendetide (Oncoscint CR/OV), a murine MoAb, was
DNA Ploidy and Cell Cycle Analysis in Cancer Diagnosis and Prognosis
June 1st 1996This review focuses on the clinical utility and potential value of cell cycle analysis and DNA ploidy interpretation in the diagnosis of human tumors, the application of these techniques to cytologic diagnosis, and their capability
Panel Recommends Hycamtin Approval for Ovarian Cancer
May 1st 1996BETHESDA, Md--The FDA's Oncologic Drugs Advisory Committee (ODAC) has unanimously recommended approval of SmithKline Beecham's Hycamtin (topotecan HCl) for the treatment of patients with metastatic ovarian cancer after failure of initial or subsequent chemotherapy.
SGO Presents Its Awards for Best Gyn Oncology Papers
May 1st 1996CHICAGO--The Society of Gynecologic Oncologists (SGO) and the Gynecologic Cancer Foundation (GCF) presented awards in four categories at the SGO's 27th annual meeting in New Orleans. The awards are funded by the GCF and were chosen from the more than 115 abstracts presented at the meeting.
IP Cisplatin Delivery Appears to Improve Ovarian Ca Outcome
April 1st 1996NEW ORLEANS--Intraperitoneal (IP) administration of cisplatin (Platinol) plus IV cyclophosphamide produced an improved outcome over IV cisplatin plus IV cyclophosphamide in a pivotal phase III ovarian cancer trial, intergroup study 0051 (SWOG-GOG-ECOG), researchers reported at the Society of Gynecologic Oncologists meeting.
Palliative Pelvic Exenteration: Patient Selection and Results
April 1st 1996In the past, the mere mention that a patient with persistent or recurrent pelvic cancer might benefit from a palliative pelvic exenteration was met with vigorous opposition. This was due, in part, to the fact that the term "palliative pelvic exenteration" was new and not clearly defined. There was also concern that the mortality, morbidity, and overall cost previously associated with pelvic exenterative procedures were out of keeping with the concept of palliation for cancer. However, much experience with pelvic exenterative surgery has been gained during the past 40 years, and the mortality, morbidity, length of stay, and overall cost of the procedure have decreased significantly. This has made the concept of pelvic exenteration for palliation reconcilable in carefully selected patients in the 1990s.
The "Epidemic" of Breast Cancer in the U.S.--Determining the Factors
April 1st 1996It is widely accepted that the causation of cancer is the result of environmental exposures (including endogenous hormone exposure) and genetic susceptibility. Ultimately, to prevent breast cancer, we must understand both the environmental and genetic components.
Genetically Altered Hematopoietic Cells Used in Transplant Research
March 1st 1996SEATTLE--Genetically modified hematopoietic cells are being used to protect healthy stem cells from toxic drugs in early clinical trials and, in cell lines, to sensitize cancer cells to toxic drugs and to induce leukemia cells to revert to a normal phenotype, Albert Deisseroth, MD, PhD, said at a symposium held in conjunction with the American Society of Hematology meeting. Dr. Deisseroth is associate director for clinical research, Yale University Cancer Center.
Topotecan Demonstrates Significant Activity in Small-Cell Lung Cancer
March 1st 1996Topotecan HCl, an investigational anticancer drug, has demonstrated significant antitumor activity in previously treated small-cell lung cancer (SCLC) patients, according to European Organization for Research and Treatment of Cancer (EORTC) researchers, who presented phase II trial data at the Eighth European Conference on Clinical Oncology, Cancer Research and Cancer Nursing (ECCO-8) in Paris.
Trial of Topotecan as First - Line Treatment for Ovarian Cancer Announced
March 1st 1996SmithKline Beecham plans to launch a study of topotecan HCl, an investigational anticancer drug, in combination with cisplatin (Platinol) for the first-line treatment of ovarian cancer. The development of this protocol was announced at the Eighth European Conference on Clinical Oncology, Cancer Research and Cancer Nursing (ECCO-8) in Paris.