March 22nd 2023
Findings from a cohort of the Childhood Cancer Survivor Study identify a prediction model that may accurately identify childhood cancer survivors at varying risks of late kidney failure.
February 25th 2023
High-Dose Chemo Before RT Results in High Survival in Pediatric Brain TumorsJune 10th 2014
High-dose chemotherapy plus conventional radiotherapy resulted in a high 3-year overall survival in children and adolescents with newly diagnosed medulloblastoma and supratentorial primitive neuroectodermal tumor.
Leukemia Risk for Children Near Power Lines?February 28th 2014
Contrary to some previous research as well as popular belief, living underneath or near to power lines as a child may not have any notable effect on childhood leukemia risk, according to a new case-control study conducted in the United Kingdom.
In Pediatric AML, CD33 Targeting Agent Improved EFS, Risk of RelapseDecember 11th 2013
Treatment with gemtuzumab ozogamicin improved the event-free survival in children and adolescents with acute myeloid leukemia by reducing the risk of relapse among those able to achieve remission, according to trial results presented at the 2013 ASH meeting.
Inherited Mutation Linked to Development of Pediatric ALLSeptember 21st 2013
A mutation of the PAX5 gene has been found to play an important role in inherited cases of B-cell precursor acute lymphoblastic leukemia (B-ALL). The mutation was isolated in two unrelated families with high propensity for B-ALL.
Dasatinib Shows Promise for Pediatric CML, ALL PatientsSeptember 13th 2013
A phase I study of dasatinib in children and adolescents with chronic myeloid leukemia (CML) and other malignancies determined dosing for further studies and suggested the drug is well tolerated and effective in these patients.
Bisphosphonate Effective in Treating Osteonecrosis Pain in Pediatric ALLJune 24th 2013
Use of the bisphosphonate pamidronate (Aredia) may be “more efficient” than standard regimens as palliative treatment for symptoms of acute symptomatic osteonecrosis in pediatric patients with acute lymphoblastic leukemia.
Methotrexate/Asparaginase Combo for Pediatric AML May Be Effective Salvage TherapyMarch 19th 2013
Combination chemotherapy with sequential administration of methotrexate and asparaginase was found to be effective salvage therapy in a small retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML).
A Tale of Two Tumors: Pediatric and Adult MedulloblastomaNovember 15th 2012
Future studies of adult medulloblastoma should include whole genome sequencing and identification of the tumorigenic cell origin of adult medulloblastoma. Ultimately, quality prospective trials are needed in adult medulloblastoma patients in order to optimize the management of this rare and complex disease.
Communication Key to Parental Decision Making for Children at End of LifeOctober 9th 2012
When facing decisions involving children with cancer at the end of life, three themes drove parental decision making--communication, extending time, and understanding prognosis, according to a recent meta-analysis.
ASCO: Crizotinib Shows Promise in Aggressive, ALK-Driven Pediatric CancersJune 4th 2012
In a phase I study the targeted drug crizotinib, a small molecule inhibitor of anaplastic lymphoma kinase and met proto oncogene, delayed or eliminated signs of tumor growth in pediatric patients with aggressive cancers.