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FDA Approves TTFields for Previously Treated Metastatic NSCLC
Support for the approval comes from phase 3 LUNAR study findings indicating TTFields significantly prolonged OS compared with standard of care alone.
Lurbinectedin Combo Yields Significant OS/PFS in ES-SCLC
Developers plan to submit a supplemental NDA for this combination as a first-line maintenance therapy for ES-SCLC in the first half of 2025.
Taste Change Data May Inform Radiotherapy Strategy in Head and Neck Cancer
Findings may help providers and patients with head and neck cancer consider whether to proceed with radiotherapy modalities, such as proton therapy or IMRT.
Cancer Vaccine Combo Does Not Improve PFS in Cervical/Anogenital Tumors
Subgroup data indicate a positive efficacy trend for TG4001 plus avelumab among patients with cervical cancer.
Evaluating Scholastic Performance in Brain Cancer Survivors Following RT
Raymond B. Mailhot, MD, MPH, discussed methods for comparing academic performances of patients following radiation therapy with healthy control groups.
Data Show Substantial Taste Changes in Head and Neck Cancer Following RT
Study results appear to affirm anecdotal information from patients with head and neck cancer related to taste changes during and after radiotherapy.
Measuring Objective Taste Changes in Head and Neck Cancer Population After RT
Noah S. Kalman, MD, MBA, describes the rationale for using a test to measure granular details of taste change in patients undergoing radiotherapy for HNC.
5-FU Bolus Omission May Reduce Toxicity, Maintain Efficacy in GI Cancers
Omitting bolus 5-fluouracil in chemotherapy-based treatment for patients with gastrointestinal cancers may reduce adverse effects and healthcare costs.
PRAME-Targeted Agent Shows Activity in Pretreated Metastatic Melanoma
Phase 1b findings may affirm the therapeutic potential of IMA203 for patients with previously treated metastatic melanoma.
Fianlimab Combo Shows Activity in Advanced Melanoma Subtypes
The safety profile of fianlimab/cemiplimab in a phase 1 trial was consistent with prior reports of cemiplimab monotherapy.
Mitigating AEs and Protecting QOL Following Talquetamab in Multiple Myeloma
Samantha Shenoy, NP, MSN, discusses how her role plays a vital part in patient care for those receiving talquetamab for multiple myeloma.
Darolutamide/ADT Improves rPFS in Metastatic HSPC
Data from the ARANOTE trial may support darolutamide plus androgen deprivation therapy as a standard of care in metastatic HSPC.
Radiotherapy/CAR T Combo May be “Great Option” in Relapsed/Refractory DLBCL
No evidence indicates synergistic toxicity when combining radiation with CAR T-cell therapy in this population, according to Timothy Robinson, MD, PhD.
Novel Allogenic CAR T Therapy Shows Responses in R/R Multiple Myeloma
P-BCMA-ALLO1 yielded lymphodepletion responses even among those with prior exposure to other CAR T-cell therapies or bispecific agents.
Bridging Radiation and CAR T-cell Therapy May Have Benefit in Relapsed/Refractory DLBCL
The addition of radiotherapy to CAR T-cell therapy may particularly benefit patients with localized disease, according to Timothy Robinson, MD, PhD.
Apalutamide Significantly Improves OS Vs Enzalutamide in Metastatic CSPC
Retrospective analysis data on apalutamide vs enzalutamide in patients with prostate cancer were consistent with findings from the phase 3 TITAN trial.
Getting to the CAR T-cell Therapy Starting Line With Radiotherapy in R/R DLBCL
Timothy Robinson, MD, PhD, discusses how radiation may play a role as bridging therapy to CAR T-cell therapy for patients with relapsed/refractory DLBCL.
Nadunolimab Combo Shows Promising Efficacy in Advanced/Metastatic PDAC
Results from the CANFOUR trial of combining nadunolimab with chemotherapy appear to prolong overall survival among those with advanced or metastatic PDAC.
Metabolic-Bariatric Surgery Reduces Pancreatic Cancer Risk in Obese Group
Regardless of type 2 diabetes status, pancreatic cancer risk was reduced with metabolic-bariatric surgery for patients who were obese.
Stereotactic Radiosurgery/TKIs Improves CNS Outcomes in EGFR/ALK+ NSCLC
Patients with non–small cell lung cancer and larger brain metastases may benefit most from the addition of up-front stereotactic radiosurgery to TKIs.
FDA Approves Inavolisib Combo in PIK3CA+ Advanced Breast Cancer
Data from the INAVO120 trial support the approval of the inavolisib combination for those with PIK3CA-mutant breast cancer.
Overcoming Barriers to Trial Enrollment and Gaps in Gynecologic Cancer Care
The Foundation for Women’s Cancer provides multicultural resources for patients with gynecologic cancers to help address gaps in care.
Talazoparib/Enzalutamide Combo Prolongs Survival in Metastatic CRPC
Detailed results from the phase 3 TALAPRO-2 trial will be submitted for presentation at a future medical meeting and shared with global health authorities.
Durvalumab Shows Manageable Safety Profile in LS-SCLC
Results showed of the phase 3 ADRIATIC study found that treatment with durvalumab elicited similar radiation pneumonitis incidences vs placebo for LS-SCLC.
Advancing Prevention and Genetic Testing Methods in Uterine Cancer
Ginger J. Gardner, MD, FACOG, addresses the growing uterine cancer cases among patients in the United States and the need for greater genetic testing.
TAR-200 Study in Muscle-Invasive Bladder Cancer Discontinued
TAR-200 plus cetrelimab did not yield significant results vs chemoradiation in muscle-invasive bladder cancer.
Raising Awareness to Address the Rising Incidence of Gynecologic Cancers
Ginger J. Gardner, MD, FACOG, discussed the state of gynecologic cancers and her role in empowering research, education, and awareness surrounding them.
Gene Expression Test May Predict Added Atezolizumab Benefit in TNBC
Phase 2 data indicate that the use of DetermaIO was predictive of a pathologic complete response with the addition of immunotherapy to chemotherapy in TNBC.
Post-Transplant Daratumumab Combo Increases MRD Negativity in NDMM
Data support the addition of daratumumab to standard lenalidomide maintenance in patients with newly diagnosed multiple myeloma following transplant.
Ongoing Consolidative RT Trial May Support Efficacy Findings in SCLC
James Ninia, MD, discussed a phase 2/3 trial seeking to answer whether complete consolidation offers more benefit than incomplete consolidation in SCLC.