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About the ActivityThis activity is based on a brief article developed as part of the E-Update Series and posted on the Web. It was developed from an identified educational need for information about practical management issues in the practice of medical, surgical, and radiation oncology. This activity has been developed and approved under the direction of CME LLC.

Oncologists remain largely satisfied with their career choice, with 85% expressing satisfaction and 82% of that group saying they would recommend their specialty to a medical student, according to a survey conducted by Epocrates, a provider of online clinical decision support tools for mobile and desktop devices.

While many oncology nurses have heard of survivor care plans, their details remain obscure. Ms. Houlihan has presented an excellent composite overview of what survivor care plans entail and the barriers limiting their use.

Once-daily oral inhibitor of mTOR (mammalian target of rapamycin) for the treatment of patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib (Sutent) or sorafenib (Nexavar).

Recognition of the growing number of cancer survivors in the United States, combined with a greater awareness of the ongoing physical and psychosocial needs after cancer treatment, has created a groundswell of interest in designing quality care initiatives for cancer survivors.

Formal recommendations for the support and management of cancer patients who are transitioning from active treatment to long-term follow-up are fairly recent, documented notably in the 2006 Institute of Medicine report, From Cancer Patient to Cancer Survivor: Lost in Transition.

Living life to the fullest is an essential goal for everyone, and cancer survivors deserve no less. Almost 12 million cancer survivors in the US today are living longer and experiencing the long-term consequences of their disease and its treatments. Nurses will be providing much of the care that these survivors will require. The quotation cited in the article by Dr. Haylock articulates the problems of survivors living with advanced cancer. The words “I can’t die yet, I still have frequent flier miles”

Cancer-related fatigue is a common side effect during cancer treatment, and research demonstrates that it is a troubling, lingering side effect for many long-term survivors. Long-term cancer survivor fatigue is under-reported, underdiagnosed, and undertreated.[1] Studies suggest that the prevalence of fatigue in breast cancer survivors may be as high as 30%,[2] and that fatigue levels are higher in cancer survivors than in healthy controls,[3] even as long as 5 years after treatment.[1]

Robyn was 63 years old when she was diagnosed with Stage III ovarian cancer. After recovering from a total abdominal hysterectomy and oopherectomy, she traveled to a comprehensive cancer center to consult with a physician specializing in ovarian cancer. She took her entire collection of pathology slides and reports, laboratory and imaging study reports, and the summary of her surgical procedure.

Could debating the actual issues get us some answers?

Shortening the course of whole-breast irradiation aft er lumpectomy from fi ve weeks to three can improve convenience and cut costs without sacrificing results, according to research from McMaster University in Hamilton, Ontario.

ORLANDO-The therapeutic pathways used for chronic myeloid leukemia patients with suboptimal response to 400 mg/d imatinib (Gleevec) tend to vary, despite the existence of NCCN clinical practice guidelines.

Society survey turns up fuel for fight against Medicare cuts.

Yet oncology drugs account for only 10% of overall U.S. spending on healthcare.

ORLANDO-The headlines declaring bevacizumab’s inability to deliver in colorectal cancer did right by the nattering nabobs of negativity:

ORLANDO-In a head-to-head comparison, two common regimens for metastatic breast cancer matched up, though the difference in toxicity profiles may give capecitabine (Xeloda) the edge over gemcitabine (Gemzar). The results “suggest that gemcitabine/docetaxel (Taxotere) followed by capecitabine at progression may be preferable,” said lead author Andrew Seidman, MD, of Memorial Sloan-Kettering Cancer Center, New York.

Micromet’s BiTE antibody blinatumomab (MT-103) elicits a high response rate in acute lymphoblastic leukemia patients with minimal residual disease, according to the Berlin-based company. The German Multicenter Acute Lymphoblastic Leukemia Study Group (GMALL) presented phase II clinical data involving the drug at the 2009 Congress of the European Hematology Association in Berlin.

Novartis’s Afinitor (everolimus) tablets shrank tumors in half for 33% of patients with relapsed non-Hodgkin’s lymphoma and Hodgkin’s disease, according to the firm. A phase II, open-label trial of 145 lymphoma patients was presented at the 2009 EHA in Berlin.

Genzyme updated information for their CLASSIC II investigational study on Clolar (clofarabine). The estimated median overall survival data was 72 weeks for patients achieving complete remission, the company said.

AstraZeneca and Merck & Co. have formed an alliance to research the combination of two investigational compounds: AZD6244 (ARRY-886) from AstraZeneca and MK-2206 from Merck. They will work together on a phase I trial and share the costs of the research.

The Commonwealth and Victorian governments have pledged $852.2 million (Aus) to create the Parkville Comprehensive Cancer Centre (Parkville CCC) in Melbourne.

Royal Philips Electronics introduced its third-generation Time-of-Flight platform for radiation oncology on its Gemini TF Big Bore PET/CT scanner at SNM 2009 in Toronto.

Houston-based investigators have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

ORLANDO-FDG-PET continues to gain ground as the go-to modality for assessing postchemotherapy response, Belgian researchers reported in a poster at ASCO 2009.

A recently released Amgen-supported survey conducted by Harris Interactive, Inc., shows that a majority of U.S. oncologists and infectious disease specialists are concerned about the rising incidence of infection among cancer patients. The data indicate another problematic issue: An increase in antibiotic resistance among immunosuppressed cancer patients.

Physicians in Congress voice their displeasure with the AMA's endorsement of the House's healthcare reform bill.

A new battle over executive versus legislative power may be shaping up.

Reishi mushroom is widely used in Asia and around the world as an immunostimulant. With extracts derived from both the cap and the stem of the mushroom, its biologic activity is thought be due to beta-glucan polysaccharides and compounds called triterpenes.

Bob Keaveney has some questions about the proposed House healthcare reform bill.

US Oncology, Inc, announced the launch of iKnowMed-an oncology-specific electronic health record (EHR) system designed by oncologists for oncologists-to the open market.